Results 241 to 250 of about 408,677 (306)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Heat Shock Proteins in Neuromuscular Diseases [PDF]

小島,　進
core  

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Xiao H, Wang B, Xiong S, Li C, Ding Y, Chao D, Mei B, Shen N, Luo G.   +8 more
europepmc   +1 more source

T cells, the next big target in axSpA?

Arthritis &Rheumatology, Accepted Article.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

A new weapon: the application of tumor vaccines based on extracellular exosomal heat shock proteins in immunotherapy. [PDF]

Front Immunol
Yi K, Sun C, Yuan Y, Luo Z, Luo H, Xie Y.   +5 more
europepmc   +1 more source

Bioinformatics analysis and alternative polyadenylation in Heat Shock Proteins 70 (HSP70) family members. [PDF]

Int J Physiol Pathophysiol Pharmacol
Shriya S, Paul R, Singh N, Afza F, Jain BP.   +4 more
europepmc   +1 more source

Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins. [PDF]

Int J Biochem Cell Biol
Paz HA, Buddha L, Lam T, Zhong Y, Sikes JD, Shankar K, Andres A, Wankhade UD.   +7 more
europepmc   +1 more source

Tumor Dormancy and Reactivation: The Role of Heat Shock Proteins. [PDF]

Cells
Amissah HA, Combs SE, Shevtsov M.
europepmc   +1 more source

The Protective Role of Heat Shock Proteins against Stresses in Animal Breeding. [PDF]

Int J Mol Sci
Liu S, Liu Y, Bao E, Tang S.
europepmc   +1 more source