Results 81 to 90 of about 213,456 (314)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Gong-kuang zidonghua, 2016 In order to solve problem of heat dissipation of host computer of mine through-the-earth communication system, a heat dissipation structure of host computer of mine through-the-earth communication based on heat technology was designed.
WANG Kan
doaj +1 more source
Water calorimetry: A correction to the heat defect calculations
Journal of Research of the National Institute of Standards and Technology, 2002 In a recent publication, we used a reaction model (model III) to calculate the heat defect for the irradiation of aqueous solutions with ionizing radiation at 21 °C. Subsequent work has revealed that the literature value used for one of the rate constants in the model was incorrect.
Klassen, Norman, Ross, Carl K.
openaire +2 more sources
Experimental investigation on self-similar heat sinks for liquid cooled electronics
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Brighenti, F +3 more
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Optimization of Thermal Processing Parameters of a High Strength Aluminum Alloy
The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2015 The work shows a calculation meant to optimize the thermal processing parameters (time and temperature) of a high strength aluminum alloy. The optimization calculation has been done by gradient method which involves multistep (iteration) calculation of ...
Marian-Iulian NEACȘU, Doru HANGANU
doaj
Yuanzineng kexue jishuTo deal with the problem that notable light water reactor decay heat calculation standard is not suitable for fast reactor, this paper adopted the sensitivity/uncertainty (S/U) method to analyze the uncertainty introduced by nuclear data in the ...
WANG Fenglong1, YANG yong1, , HUANG Xiaolong2
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Digital Twin-based Framework for Heat Stress Calculation [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information SciencesAccording to the KNMI Klimaatsignaal’21, the average surface temperature in The Netherlands has increased by 2.3°C between 1901 and 2020. Moreover, The Netherlands is also experiencing more frequent and intense heatwaves.
I. Cárdenas-León +4 more
doaj +1 more source