Results 61 to 70 of about 213,456 (314)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Heat Load Calculation

open access: yes, 2019
The primary objective of this report is to provide a convenient, consistent and accurate method of calculating heating and cooling loads and to enable the designer to select systems that meet the requirement for efficient utilization and are also responsive to environmental needs.
Junaid Hussain, Gaffar, Syed Abdul
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Sensitivity of the Heat-Transfer Coefficient Calculation [PDF]

open access: yesMaterials Performance and Characterization, 2014
AbstractThe purpose of the Liščić/Petrofer probe is to determine the cooling intensity during liquid quenching in laboratory and workshop environments. The surface heat-transfer coefficient is calculated by the one-dimensional finite-volume method from the smoothed temperature curve, measured at a near-surface point in the probe.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Calculation and Application of Charging Material and Heat Balance in 150 t Top and Bottom Combined Blown Converter

open access: yesTeshugang, 2011
Based on data of 150 t converter steelmaking at Anyang Steel, the calculation of charging material balance and heat balance have been carried out and a calculation model is established.
吕亚   +5 more
doaj  

Simplified modelling of air source heat pumps producing detailed results

open access: yes, 2012
Created by the Building Research Establishment (BRE), the Standard Assessment Procedure (SAP) is the UK Government‟s recommended method of assessing the energy ratings of dwellings.
Baster, Michael Eric   +3 more
core  

CFD prediction of coupled radiation heat transfer and soot production in turbulent flames [PDF]

open access: yes, 1996
The mechanisms governing the formation and destruction of soot in turbulent combustion are intimately coupled to thermal radiation due to the strong dependence of sooting processes and radiative loss on temperature.
Bressloff, N., Bressloff, N. W.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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