Results 91 to 100 of about 349,085 (279)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Research on the influencing factors of contact heat conduction between sliding rough surfaces

open access: yes矿业科学学报, 2019
The contact heat conduction problem between the rough sliding surfaces was studied through secondary development of finite element software ABAQUS.The thermal contact conductance was defined as a function of the sliding speed,the local contact pressure ...
Liu Yuwei   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Effect of Gradient Heat Conduction on Secondary Recrystallization of Grain-Oriented Silicon Steel

open access: yesMetals
The grain-oriented silicon steels were subjected to gradient heat conduction during high-temperature annealing by using thermal insulation cotton. The macrostructures of samples subjected to circumferential gradient heat conduction showed a “petal-like ...
Qian Gao   +5 more
doaj   +1 more source

Shape sensitivity for a two-phase heat conduction problem considering nanoscale effects

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Thermal design is essential when developing various types of technological devices, especially miniaturized electronic devices. Conventional thermal design methods that only focus on macrostructures can provide only limited improvements in electronic ...
Kozo FURUTA   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

The Self-limiting Nature of Jet-modulated Thermal Conduction in Cool Core Clusters

open access: yesThe Astrophysical Journal
Conduction as a mechanism for explaining the disrupted cooling-flow in galaxy clusters has been mostly discounted, as the process is inefficient at transporting heat all the way from the cluster into the core.
Jennifer N. Stafford   +4 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Research on mitigation strategies for axial heat conduction in cryogenic microchannel heat exchangers

open access: yesCase Studies in Thermal Engineering
The compact design of microchannel heat exchangers (MCHX) offers significant advantages for their utilization in cryogenic systems, but it is accompanied by serious axial heat conduction problems.
Tao Zhu   +4 more
doaj   +1 more source

Fractional single-phase-lagging heat conduction model for describing anomalous diffusion

open access: yesPropulsion and Power Research, 2016
The fractional single-phase-lagging (FSPL) heat conduction model is obtained by combining scalar time fractional conservation equation to the single-phase-lagging (SPL) heat conduction model.
T.N. Mishra, K.N. Rai
doaj   +1 more source

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