Results 91 to 100 of about 350,035 (281)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Research on mitigation strategies for axial heat conduction in cryogenic microchannel heat exchangers

Case Studies in Thermal Engineering
The compact design of microchannel heat exchangers (MCHX) offers significant advantages for their utilization in cryogenic systems, but it is accompanied by serious axial heat conduction problems.
Tao Zhu, Xiaoli Duan, Bingcheng Wang, Cheng Shao, Zheng Cui   +4 more
doaj   +1 more source

Fractional single-phase-lagging heat conduction model for describing anomalous diffusion

Propulsion and Power Research, 2016
The fractional single-phase-lagging (FSPL) heat conduction model is obtained by combining scalar time fractional conservation equation to the single-phase-lagging (SPL) heat conduction model.
T.N. Mishra, K.N. Rai
doaj   +1 more source

Identification of nonlinear heat conduction laws

, 2014
We consider the identification of nonlinear heat conduction laws in stationary and instationary heat transfer problems. Only a single additional measurement of the temperature on a curve on the boundary is required to determine the unknown parameter ...
Egger, Herbert, Pietschmann, Jan-Frederik, Schlottbom, Matthias   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fresnel transmission coefficients for thermal phonons at solid interfaces [PDF]

, 2015
Interfaces play an essential role in phonon-mediated heat conduction in solids, impacting applications ranging from thermoelectric waste heat recovery to heat dissipation in electronics.
Chen, Xiangwen, Hua, Chengyun, Minnich, Austin J., Ravichandran, Navaneetha K.   +3 more
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A Dimensionless Number for Evaluating the Influence of Heat Conduction in the Gas Phase on Liquid Evaporation

Energies
Heat conduction in the gas phase may influence liquid evaporation, yet a quantitative characterization of this effect still remains lacking. Here, through dimensionless analysis of the theoretical model for droplet evaporation, two limiting solutions ...
Longfei Xu, Xuefeng Xu
doaj   +1 more source