Results 71 to 80 of about 63,087 (257)
EnergiesIn this study, the influence of residual gas pressure within a vacuum insulation cavity on the insulation performance of a multi-layer insulation (MLI) system was investigated through thermal analysis. Based on an electrical analogy, a thermal resistance
Tae Yun Lee, Jeong Soo Kim
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Heat conduction in nanostructured materials
Journal of Thermal Science and Technology, 2016 An overview of the direct and ab initio simulation as well as experimental tools addressing heat conduction in dielectric nanostructures and nanostructured materials is proposed.
Sebastian VOLZ +3 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Fractional Heat Conduction in an Infinite Medium with a Spherical Inclusion
Entropy, 2013 The problem of fractional heat conduction in a composite medium consisting of a spherical inclusion (0< r < R) and a matrix (R
Yuriy Povstenko
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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Research on the influencing factors of contact heat conduction between sliding rough surfaces
矿业科学学报, 2019 The contact heat conduction problem between the rough sliding surfaces was studied through secondary development of finite element software ABAQUS.The thermal contact conductance was defined as a function of the sliding speed,the local contact pressure ...
Liu Yuwei +3 more
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