Results 51 to 60 of about 63,087 (257)

Freezing of Biological Tissues During Cryosurgery Using Hyperbolic Heat Conduction Model

open access: yesMathematical Modelling and Analysis, 2015
This paper considers hyperbolic heat conduction model for biological tissue freezing during cryosurgery with non ideal property of tissue, metabolism and blood perfusion.
Sonalika Singh, Sushil Kumar
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Heat guiding and focusing using ballistic phonon transport in phononic nanostructures

open access: yesNature Communications, 2017
Heat conduction at the nanoscale is unlike macroscopic diffusion and phonons can travel in straight lines without dissipation. Here Anufrievet al. show that heat conduction can be spatially directed in nanostructured silicon and exploit this effect to ...
Roman Anufriev   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Explicit Time Integration Method Based on Uniform Trigonometric B-Spline Function for Transient Heat Conduction Analysis

open access: yesApplied Sciences
In this paper, a new explicit time integration method for transient heat conduction analysis is proposed based on the uniform trigonometric B-spline function. The algorithmic calculation procedure for solving the heat conduction problem is given.
Zixu Li   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The Estimation of surface heat fluxes based on physics-informed neural network

open access: yesKongqi donglixue xuebao
The problem of estimating surface heat fluxes is a typical inverse heat conduction problem. To solve this problem, the estimation of surface heat fluxes based on physics-informed neural network(PINN) is proposed.
Xiancai Zhang   +4 more
doaj   +1 more source

Barycentric Rational Collocation Method for Nonlinear Heat Conduction Equation

open access: yesJournal of Applied Mathematics, 2022
Nonlinear heat equation solved by the barycentric rational collocation method (BRCM) is presented. Direct linearization method and Newton linearization method are presented to transform the nonlinear heat conduction equation into linear equations.
Jin Li
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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