Results 111 to 120 of about 189,544 (307)
Decarbonisation of heat: How SLES can contribute
, 2022 Decarbonisation of heat is an immense challenge. Despite accounting for over a third of the UK’s carbon emissions, little progress has been made in decarbonising heat.
Radcliffe, Jonathan +5 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2013 Climate change and continuously increasing energy prices have driven the need for low carbon and renewable energy technologies from different sectors, including the domestic sector, by installing higher energy efficiency technologies.
Samir, Karmacharya
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 1983 The Demand Management Plan set forth in this paper has proven to be a viable action to reduce a 3 million per year electric bill at the Columbus Works location of Western Electric.
Fetters, J. L., Teets, S. J.
core
How Heat-Powered Heat Pumps Could Reduce the Need for Grid-Scale Energy Storage
This paper explores how the deployment of "High-Performance Heat-Powered Heat Pumps" (HP 3 s)-a novel heating technology-could help meet the domestic heating demand in the UK and reduce how much grid-scale energy storage is needed in comparison to a ...
Cardenas, Bruno +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Heat demand data for Edinburgh-Gogarbank in 2013
, 2015 Heat demand data generated with a synthetic heat demand model from external temperature, annual heat demand and occupancy ...
Friedrich, Daniel, Renaldi, Renaldi
core +2 more sources