Results 131 to 140 of about 965,939 (262)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
‘Greening’ the UK: A Comparative Study of Heat Pumps and Hydrogen Boilers in Residential Heating
EnergiesWith a key policy decision on the role of hydrogen boilers expected by 2026, the UK is at a strategic crossroads in implementing its Heat and Buildings Strategy.
Lin Gao +3 more
doaj +1 more source
Enabling Demand Side Management: Heat Demand Forecasting at City Level. [PDF]
Materials (Basel), 2019 Hietaharju P, Ruusunen M, Leiviskä K.
europepmc +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Computing Residential Heat Demand in Urban Space using QGIS. A Case Study for Shumen, Bulgaria [PDF]
, 2016 Smart Cities need Smart Energy Planning. This requires knowledge about the spatial configuration of building heat demand, to facilitate circumspect decisions about where and how to renovate the building stock and what type of heating supply technology to
Dochev, Ivan
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Case Studies in Thermal EngineeringTransitioning from natural gas to cleaner heating methods is crucial for reducing carbon emissions. Heat pumps, which extract heat from air, water, or geothermal sources, offer an efficient alternative but significantly increase peak electricity demand ...
Ramin Mehdipour +4 more
doaj +1 more source
DIMENSION - A Dispatch and Investment Model for European Electricity Markets [PDF]
A linear energy system model is presented which optimises the future development of electricity generation capacities and their dispatch in Europe. Besides conventional power plants, combined heat and power plants and power storages, the model considers ...
Richter, Jan
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source