Results 71 to 80 of about 965,939 (262)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Predictive Optimization of the Heat Demand in Buildings at the City Level
Applied Sciences, 2019 Easily adaptable indoor temperature and heat demand models were applied in the predictive optimization of the heat demand at the city level to improve energy efficiency in heating.
Petri Hietaharju +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Forecasting Heat Demand of Residential Buildings Connected to District Heating: The Case of Riga
Environmental and Climate TechnologiesA large proportion of greenhouse gas emissions come from heating and hot water supply and developed district heating systems will play an important role in meeting climate targets.
Rieksta Madara +3 more
doaj +1 more source
Performance assessment of tariff-based air source heat pump load shifting in a UK detached dwelling featuring phase change-enhanced buffering [PDF]
, 2014 Using a detailed building simulation model, the amount of thermal buffering, with and without phase change material (PCM), needed to time-shift an air source heat pump's operation to off-peak periods, as defined by the UK 'Economy 10' tariff, was ...
Hawkes, Adam D. +2 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Decarbonizing European Industry: A Novel Technology to Heat Supply Using Waste and Renewable Energy
Applied SciencesThis study examines the potential for the smart integration of waste and renewable energy sources to supply industrial heat at temperatures between 150 °C and 250 °C, aiming to decarbonize heat demand in European industry. This work is part of a European
José Daniel Marcos +3 more
doaj +1 more source
Integration of Biohydrogen Production with Heat and Power Generation from Biomass Residues
Chemical Engineering Transactions, 2013 The employment of renewable sources rather than fossil fuels in the production of hydrogen is an important step to achieve a sustainable hydrogen economy in the future.
W. Wukovits +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source