Results 81 to 90 of about 3,389,680 (300)

Establishment of performance evaluation indicators for low-temperature multi-effect seawater desalination equipment and analysis of typical engineering datas

open access: yesGongye shui chuli
By investigating the design and operation of low-temperature multi-effect seawater desalination (LT-MED) projects distillation equipment in power, steel, petrochemical and other industries supported by domestic, the performance evaluation indicators of ...
QI Chunhua
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Integration of Biohydrogen Production with Heat and Power Generation from Biomass Residues

open access: yesChemical Engineering Transactions, 2013
The employment of renewable sources rather than fossil fuels in the production of hydrogen is an important step to achieve a sustainable hydrogen economy in the future.
W. Wukovits   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Demand Response Design of Domestic Heat Pumps

open access: yesDesigns, 2017
This paper proposes an emergency-based demand response (DR) controller of domestic heat pump (DHP) units based on an estimated frequency of the UK electricity in 2035.
Mohammed Jasim M. Al Essa
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

City Scale Demand Side Management in Three Different-Sized District Heating Systems

open access: yesEnergies, 2018
Demand side management can add flexibility to a district heating (DH) system by balancing the customer’s hourly fluctuating heat demand. The aim of this study is to analyze how different demand side management control strategies, implemented into ...
Kaisa Kontu   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

The Forecasting of the Daily Heat Demand of the Public Sector Buildings with District Heating

open access: yes, 2015
This study is devoted to the increasing of the heat energy demand forecasting accuracy for district heating of the public sector buildings.
Yuliia Parfenenko   +3 more
openaire   +2 more sources

Heat transfer in flat-plate boundary layers: a correlation for laminar, transitional, and turbulent flow

open access: yes, 2020
The laminar and turbulent regimes of a boundary layer on a flat plate are often represented with separate correlations under the assumption of a distinct “transition Reynolds number.” Average heat coefficients are then calculated by integrating across ...
Lienhard, John H, Lienhard, John H.
core   +1 more source

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