Results 71 to 80 of about 152,514 (266)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
City Scale Demand Side Management in Three Different-Sized District Heating Systems
Energies, 2018 Demand side management can add flexibility to a district heating (DH) system by balancing the customer’s hourly fluctuating heat demand. The aim of this study is to analyze how different demand side management control strategies, implemented into ...
Kaisa Kontu +3 more
doaj +1 more source
Irish residential heating demand profile dataset
Data in BriefThis data article describes the operation of gas and oil fuelled residential heating systems in Ireland. Based on almost 10,000 homes, the data presents information on the operation of domestic heating systems (whether turned on/off by the user), and the firing of the boiler during 2-hour slots across a period of two years ending in September 2021 by ...
John Curtis, Niall Farrell
openaire +2 more sources
The Forecasting of the Daily Heat Demand of the Public Sector Buildings with District Heating
, 2015 This study is devoted to the increasing of the heat energy demand forecasting accuracy for district heating of the public sector buildings.
Yuliia Parfenenko +3 more
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Demand Response Design of Domestic Heat Pumps
Designs, 2017 This paper proposes an emergency-based demand response (DR) controller of domestic heat pump (DHP) units based on an estimated frequency of the UK electricity in 2035.
Mohammed Jasim M. Al Essa
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Nauka ta progres transportu, 2014 Purpose. Heat consumption for heating and hot water supply of housing and industrial facilities is an essential part of heat energy consumption. Prerequisite for development of energy saving measures in existing heating systems is their preliminary ...
O. M. Pshinko +2 more
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source