Results 81 to 90 of about 1,183,195 (322)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A Novel Numerical Approach for Solving Initial Value Problems in Heat Equations Using Variational Regularization and Intelligent Particle Swarm Optimization

Proceedings of the International Conference on Applied Innovations in IT
In this article, we use the variational approach as a regularization tool to solve the initial value problem which appear in a heat partial differential equation.
H.K. Al-Mahdawi, Kilan M. Hussien, Ghassan K. Ali, Fadhil Kadhem Zaidan, Ali Subhi Alhumaima, Hussein Alkattan   +5 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Determination of a source term for a time fractional diffusion equation with an integral type over-determining condition

Electronic Journal of Differential Equations, 2013
We consider a linear heat equation involving a fractional derivative in time, with a nonlocal boundary condition. We determine a source term independent of the space variable, and the temperature distribution for a problem with an over-determining ...
Timurkhan S. Aleroev, Mokhtar Kirane, Salman A. Malik   +2 more
doaj  

Self-similar solutions of a multi-phase Stefan problem on the half-line

Современная математика: Фундаментальные направления
In this paper, we study self-similar solutions of the multiphase Stefan problem for the heat equation on the half-line x 0 with constant initial data and Dirichlet or Neumann boundary conditions. In the case of the Dirichlet boundary condition, we prove
E. Yu. Panov
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

New coherent states and modified heat equations

, 2013
We clarify the relations between certain new coherent states for loop quantum gravity and the analytically continued heat kernel coherent states, highlighting the underlying general construction, the presence of a modified heat equation as well as the ...
Pittelli, Antonio, Sindoni, Lorenzo
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Optimal design of a bar with an attached mass for maximizing the heat transfer

Electronic Journal of Differential Equations, 2012
We maximize, with respect to the cross sectional area, the rate of heat transfer through a bar of given mass. The bar serves as an extended surface to enhance the heat transfer surface of a larger heated known mass to which the bar is attached.
Boris P. Belinskiy, James W. Hiestand, Maeve L. McCarthy   +2 more
doaj