Results 71 to 80 of about 257,535 (310)

Finding the one-loop soliton solution of the short-pulse equation by means of the homotopy analysis method

, 2009
The homotopy analysis method is applied to the short-pulse equation in order to find an analytic approximation to the known exact solitary upright-loop solution. It is demonstrated that the approximate solution agrees well with the exact solution.
Abbasbandy, S., Parkes, E.J.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Entransy, Entransy Dissipation and Entransy Loss for Analyses of Heat Transfer and Heat-Work Conversion Processes

Journal of Thermal Science and Technology, 2013
Entransy is a parameter proposed in recent years to describe the potential of heat in an object. Its balance equation was established based on the energy equation of heat transfer, which contains entransy, entransy flow, entransy dissipation and entransy
XueTao CHENG, XinGang LIANG
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Fractional Derivative Modeling of Heating and Cooling of LED Luminaires

Mathematics, 2020
In the context of energy efficient lighting, we present a mathematical study of the heating and cooling processes of a common type of luminaires, consisting of a single light-emitting diode source in thermal contact with an aluminum passive heat sink ...
Eduardo Balvís, Angel Paredes, Iván Area, Ricardo Bendaña, Alicia V. Carpentier, Humberto Michinel, Sonia Zaragoza   +6 more
doaj   +1 more source

Coupling Mesoscopic Boltzmann Transport Equation and Macroscopic Heat Diffusion Equation for Multiscale Phonon Heat Conduction

, 2020
International audiencePhonon heat conduction has to be described by the Boltzmann transport equation (BTE) when sizes or sources are comparable to or smaller than the phonon mean free paths (MFPs).
Alkurdi, Ali, Chapuis, P.-O., Cheng, Weizheng   +2 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Boundary element formulations for the numerical solution of two-dimensional diffusion problems with variable coefficients [PDF]

, 2012
This is the post-print version of the final paper published in Computers & Mathematics with Applications. The published article is available from the link below.
Škerget, L, Ravnik, J., AL-Jawary, M.A., Al-Jawary, MA, Wrobel, L.C., Wrobel, LC, Škerget, L., Ravnik, J   +7 more
core   +1 more source