Results 41 to 50 of about 1,096,222 (292)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Carbon footprint analysis of wastewater treatment processes coupled with sludge in situ reduction

Water Research X
The goal of this study was to assess the impacts or benefits of sludge in situ reduction (SIR) within wastewater treatment processes with relation to global warming potential in wastewater treatment plants, with a comprehensive consideration of ...
Yiyue Sun, Yi Zuo, Yanjun Shao, Lihua Wang, Lu-Man Jiang, Jiaming Hu, Chuanting Zhou, Xi Lu, Song Huang, Zhen Zhou   +9 more
doaj   +1 more source

Numerical simulation of heat transfer performance of spiral wound heat exchanger under sloshing condition.

PLoS ONE, 2023
LNG floating production storage and offloading (FPSO) unit is a new type of floating production unit developed for offshore natural gas fields. It performs the functions of natural gas extraction, pretreatment, liquefaction, and storage.
Longfei Dong, Congcong Dong, Xiao Wu
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Maturity effects in concrete dams [PDF]

, 2004
Model equations for determining the coupled heat, moisture and maturity changes within a concrete block are introduced and briefly examined. Preliminary results are obtained for the heat exchange between concrete slabs in contact driven by maturity ...
Ballim, Y, Fowkes, ND, Makinde, OD, Mambili Mamboundou, H, Patini, A   +4 more
core  

Heat transport in stochastic energy exchange models of locally confined hard spheres

, 2009
We study heat transport in a class of stochastic energy exchange systems that characterize the interactions of networks of locally trapped hard spheres under the assumption that neighbouring particles undergo rare binary collisions.
Bonetto F, Chernov N, Gaspard G, Gaspard G, Krámli A, Pierre Gaspard, Thomas Gilbert   +6 more
core   +1 more source

Kurtosis-Based State of Health Prediction of Lithium-Ion Batteries Using Probability Density Function

Electrochemistry
Lithium-ion batteries are widely used as power sources for various devices, so rapid and accurate estimation of the health status of lithium-ion batteries is an important means to reduce battery failures.
Yinsen YU, Yongxiang CAI, Wei LIU, Zhenlan DOU, Bin YAO, Bide ZHANG, Qiangqiang LIAO, Zaiguo FU, Zhiyuan CHENG   +8 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source