Results 51 to 60 of about 235,946 (314)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
PLoS ONE, 2023 LNG floating production storage and offloading (FPSO) unit is a new type of floating production unit developed for offshore natural gas fields. It performs the functions of natural gas extraction, pretreatment, liquefaction, and storage.
Longfei Dong, Congcong Dong, Xiao Wu
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2013 Understanding the subsurface heat exchange process in enhanced geothermal systems (EGS) is crucial to the efficiency of heat extraction and the sustainable utilization of geothermal reservoir.
Luo, Liang +2 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2021 We analyze the role of mesoscale heat advection in the Southern Ocean mixed layer (ML) heat budget using a regional high-resolution coupled model, with realistic atmospheric forcing and an idealized ocean component.
Perlin, Natalie +3 more
core +1 more source
Carbon footprint analysis of wastewater treatment processes coupled with sludge in situ reduction
Water Research XThe goal of this study was to assess the impacts or benefits of sludge in situ reduction (SIR) within wastewater treatment processes with relation to global warming potential in wastewater treatment plants, with a comprehensive consideration of ...
Yiyue Sun +9 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
ElectrochemistryLithium-ion batteries are widely used as power sources for various devices, so rapid and accurate estimation of the health status of lithium-ion batteries is an important means to reduce battery failures.
Yinsen YU +8 more
doaj +1 more source