Results 61 to 70 of about 235,946 (314)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The effects of heat exchange and fluid production on the ignition of a porous solid

, 2008
In this paper we study a system of nonlinear parabolic equations representing the evolution of small perturbations in a modeldescribing the combustion of a porous solid.
McIntosh, A.C., Brindley, J., Shah, Akeel A., McIntosh, A. C., Rademacher, Jens, Rademacher, J.D.M. (Jens), Shah, A.A., McIntosh, A., Rademacher, J.   +8 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Sensible and latent heat flux from radiometric surface temperatures at the regional scale: methodology and validation

, 2009
The CarboEurope Regional Experiment Strategy (CERES) was designed to develop and test a range of methodologies to assess regional surface energy and mass exchange of a large study area in the south-western part of France.
Brunet, Y., Hutjes, R.W.A., Sarrat, C., Zaldei, A., Miglietta, Francesco, Sarrat, Charlotte, Gioli, B., Matese, A., Miglietta, F., Brunet, Yves   +9 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Optimization of the heat exchange system of the gasoline fraction hydrotreating unit

Известия высших учебных заведений: Нефть и газ, 2022
This article deals with the main trends of improving the energy efficiency of production facilities for processing hydrocarbon materials on the example of a catalytic reforming unit.
L. V. Taranova, G. P. Klevtsov, A. G. Mozyrev   +2 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

R32 Partial Condensation Inside A Brazed Plate Heat Exchanger

, 2012
It is well known that when a superheated gas reaches a cold surface, the condensation starts immediately only if the wall temperature is lower than the dew temperature of the refrigerant; in this case, the heat transfer phenomenon can be also affected by
Mancin, Simone, Rossetto, Luisa, Del Col, Davide   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study on the random walk classification algorithm of polyant colony

Open Computer Science, 2022
With the sustained and healthy development of economy, saving energy and reducing consumption and improving energy utilization rate is a major task that enterprises need to solve.
Qiu Wenhai
doaj   +1 more source