Results 101 to 110 of about 123,959 (281)

On the Possibility of "Dry" Friction in Superfluid He-4

, 2011
We propose a possible microscopic explanation of the exhaustion of \rho_s of helium-II on the wall at T>T_{c} = 0.5 - 1 K and predict a possibility of the existence in He-II of the "dry" friction at T < T_{c}.
Tomchenko, Maksim D.
core  

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Elevated core temperature in addition to mental fatigue impairs aerobic exercise capacity in highly trained athletes in the heat

Journal of Physiological Anthropology
The purpose of this study was to investigate the effects of elevated core temperature by exposure to heat stress vs. heat exposure without elevated core temperature (mean skin temperature only) in addition to mental fatigue on aerobic exercise capacity ...
Takashi Naito, Tatsuya Saito, Hirotsugu Morinaga, Nobuhiko Eda, Yohei Takai   +4 more
doaj   +1 more source

Model Aktivitas Praktikum Lapangan Berbasis Ergonomi (Apelerg) Memperbaiki Respon Fisiologis Tubuh, Menurunkan Kelelahan, dan Meningkatkan Kinerja, Dibandingkan dengan Model Lama (Apel), pada Mahasiswa Fmipa Unima [PDF]

, 2009
Aktivitas praktikum lapangan merupakan kegiatan yang dilakukan sebagaiimplementasi kurikulum akademik di Jurusan Fisika FMIPA UNIMA. Sebagaiimplementasi kurikulum tersebut telah dibuat model aktivitas praktikum lapangan (modelAPeL) dan telah digunakan ...
Adiputra, N. (Nyoman), Manuaba, A. (Adnyana), Palilingan, R. (Rolles), Pangkahila, A. (Alex)   +3 more
core  

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

The Safe Recipient of SSC Transplantation Prepared by Heat Shock With Busulfan Treatment in Mice

Cell Transplantation, 2018
Safety is the chief consideration in recipient preparation of spermatogonial stem cell (SSC) transplantation in mammals, especially humans. In this study, we compared the safety of the SSC transplantation recipients that were prepared both by testes heat
Wenzhi Ma, Jia Wang, Weijun Gao, Hua Jia
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness

Journal of Nutrition and Metabolism
A rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat-related illnesses such as exertional heat exhaustion and stroke.
Micah Zuhl, Jonathan Specht, Sage Beatty, Christine Mermier   +3 more
doaj   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source