Results 81 to 90 of about 1,595,198 (282)

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

The gut-liver axis plays a limited role in mediating the liver’s heat susceptibility of Chinese giant salamander

BMC Genomics
The Chinese giant salamander (CGS, Andrias davidianus), a flagship amphibian species, is highly vulnerable to high temperatures, posing a significant threat under future climate change.
Runliang Zhai, Chunlin Zhao, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang, Wei Zhu   +6 more
doaj   +1 more source

Noise reduction in heat pumps

, 2001
If not designed and installed properly in a suitable location, heat pumps can produce noise at nuisance levels for adjacent residents. Various (national and international) systems and guidelines used for measuring, predicting and regulating noise levels ...
Eggenschwiler, Kurt (author), Studer, Markus (author)   +1 more
core   +1 more source

Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks

Advanced Science, EarlyView.
Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley   +1 more source

A Case of Legionnaires' Disease Manifesting as Heat Exhaustion. [PDF]

Cureus, 2023
Malik MA, Shaukat F, Malik A, Kaifee S, Eid M.   +4 more
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Factors Related To Heat Strain In Tough-Making Industry Workers In Kotabumi Selatan District, North Lampung District

Professional Health Journal
Tofu industry workers are a group vulnerable to heat strain due to high heat exposure during work. Heat strains can cause serious health problems such as heat stroke, heat exhaustion, and heat cramps.
Dony Mahendra, Nurul Aziza, Nana Novariana   +2 more
doaj   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Assessment of downhole heat exchangers in Puna district, Hawaii

, 2007
"Downhole heat exchangers (DHEs) have the potential for use in direct (non-electric) applications of geothermal energy. Their benefit is that no groundwater is extracted from wells.
Geo-Heat Center, Oregon Institute of Technology
core   +2 more sources

Analysis of heat stroke and heat exhaustion cases in EudraVigilance pharmacovigilance database. [PDF]

Eur J Clin Pharmacol, 2023
Gamboa L, Lafuente AS, Morera-Herreras T, Garcia M, Aguirre C, Lertxundi U.   +5 more
europepmc   +1 more source