Results 101 to 110 of about 182,887 (314)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Airborne water vapour and wind lidar measurements of latent heat fluxes during COPS 2007

, 2010
During the Convective and Orographically-induced Precipitation Study (COPS) in July 2007 over the Black Forest Mountains in south-western Germany, tropospheric profiles of water vapour and wind were measured with a differential absorption lidar (DIAL ...
Kiemle, Christoph, Fix, Andreas, Rahm, Stephan, Wirth, Martin   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Measurement and parameterisation of the air-sea CO2 flux in high winds

, 2011
During a three year occupation of Station Mike (66°N 2°E), the Norwegian Ocean Weather Ship Polarfront was equipped with a range of meteorological and seastate measuring instruments, including the autonomous air-sea flux system “AutoFlux” (Yelland et al.,
Prytherch, John
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Latent Heat Fluxes over Complex Terrain from Airborne Water Vapour and Wind Lidars

, 2009
Tropospheric profiles of water vapour and wind were measured with a differential absorption lidar (DIAL) and a heterodyne detection Doppler wind lidar collo-cated onboard the DLR Falcon research aircraft in the past two years.
Kiemle, Christoph, Fix, Andreas, Rahm, Stephan, Wirth, Martin   +3 more
core  

Experimental investigation of non-uniform heating effect on flow boiling instabilities in a microchannel-based heat sink

, 2011
Copyright @ 2011 ElsevierTwo-phase flow boiling in microchannels is one of the most promising cooling technologies for coping with high heat fluxes produced by the next generation of central processor units (CPUs).
Bogojevic, D, Cummins, G, Karayiannis, T. G., T.G. Karayiannis, Lin, H., H. Lin, D. Bogojevic, K. Sefiane, D.B.R. Kenning, A.J. Walton, G. Cummins, Lin, H, Sefiane, K, Sefiane, K., Walton, AJ, Walton, A. J., Cummins, G.; id_orcid, Bogojevic, D., Karayiannis, TG, Kenning, DBR, Kenning, D. B. R.   +20 more
core   +1 more source

Heat Flux at the Surface of Metal Foil Heater under Evaporating Sessile Droplets

International Journal of Aerospace Engineering, 2015
Evaporating water drops on a horizontal heated substrate were investigated experimentally. The heater was made of a constantan foil with the thickness of 25 μm and size of 42 × 35 mm2.
Igor Marchuk, Andrey Karchevsky, Anton Surtaev, Oleg Kabov   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Ignition of a rectangular solid by an external heat flux

, 1994
The influence of corners on the ignition of a solid exposed to a surface energy flux is analyzed with large activation energy asymptotics. We begin with the analysis of the ignition of semi-infinite wedges by a constant heat flux.
Vázquez Espí, Carlos, Liñán Martínez, Amable   +1 more
core