Results 71 to 80 of about 701,963 (354)
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Thermal and electrical conductivity of iron at Earth's core conditions [PDF]
, 2012 The Earth acts as a gigantic heat engine driven by decay of radiogenic isotopes and slow cooling, which gives rise to plate tectonics, volcanoes, and mountain building.
A Jackson +41 more
core +2 more sources
Model Investigation of Subcooled Flow Boiling in Narrow Rectangular Channel Using CFD Method
Yuanzineng kexue jishu, 2022 The plate-type fuel assembly with the advantages of high specific power of active zone and compact structure has been widely adopted in many research reactors and material irradiation test reactors.
LIU Kai;LI Linfeng;WANG Mingjun;ZHANG Jing;TIAN Wenxi;QIU Suizheng;SU Guanghui
doaj
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Plug-type heat flux gauge [PDF]
, 1991 A plug-type heat flux gauge formed in a material specimen and having a thermoplug integrally formed in the material specimen, and a method for making the same are disclosed. The thermoplug is surrounded by a concentric annulus, through which thermocouple
Koch, John, Jr., Liebert, Curt H.
core +1 more source
Application of the Critical Heat Flux Look-Up Table to Large Diameter Tubes
Science and Technology of Nuclear Installations, 2013 The critical heat flux look-up table was applied to a large diameter tube, namely 67 mm inside diameter tube, to predict the occurrence of the phenomenon for both vertical and horizontal uniformly heated tubes. Water was considered as coolant.
M. El Nakla +5 more
doaj +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Control of heat flux using computationally designed metamaterials [PDF]
, 2016 To gain control over the diffusive heat flux in a given domain, one has to design metamaterials with a specifc distribution of the generally anisotropic thermal conductivity throughout the domain.
Ciarbonetti, A. +3 more
core
Divertor Heat Load in ASDEX Upgrade L-Mode in Presence of External Magnetic Perturbation [PDF]
, 2017 Power exhaust is one of the major challenges for a future fusion device. Applying a non-axisymmetric external magnetic perturbation is one technique that is studied in order to mitigate or suppress large edge localized modes which accompany the high ...
Eich, Thomas +5 more
core +3 more sources