Results 91 to 100 of about 4,691,836 (302)
Journal of Numerical Analysis and Approximation Theory, 2008 An analytical study of the steady magnetohydrodynamics (MHD) free convection in an tall cavity filled with a fluid-saturated porous medium and with internal heat generation has been performed. It is considered that the Darcy law model is used.
Cornelia Revnic +2 more
doaj
Constructal structures for self-cooling microvascular wavy and straight channels
Journal of Thermal Engineering, 2015 This paper shows that a conductive domain which is subjected to heating from its bottom can be cooled with embedded microvascular cooling channels in it. The volume of the domain and the coolant are fixed.
Erdal Çetkin
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Механика машин, механизмов и материалов, 2018 The paper shows that in the root of rectangular grooves of stretched steel cylindrical rods of circular cross section containing groups of equally distant grooves with the same geometry, with an increase in the distance between the grooves, the relative ...
Yurij V. Vasilevich +2 more
doaj
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Component parts of the World Heat Flow Data Collection
, 2013 This data set is a compilation of heat flow data of uncertain origin. References as cited in Global Heat Flow Database were incomplete and thus could not be verified.
Global Heat Flow Compilation Group +1 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source