Results 71 to 80 of about 4,691,836 (302)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Experimental determination of natural convection heat transfer coefficients in an attic shaped enclosure [PDF]
, 2010 Heat transfer by natural convection in triangular enclosures is an area of significant importance in applications such as the design of greenhouses, attics and solar water heaters.
Carson, James K. +5 more
core +1 more source
Carbon footprint of the energy sector
RUDN Journal of Ecology and Life SafetyThe world's attention is focused on the anthropogenic component of climate change. The energy sector (77.9%) makes a significant contribution to these changes.
Leysan R. Gainullina +3 more
doaj +1 more source
Navier Slip Condition on Time-Dependent Radiating Nanofluid with the Soret Effect
Engineering Transactions, 2020 This work concentrates on the study of the two-dimensional hydromagnetic flow of nanofluids over an suddenly started nonlinear stretching sheet in the presence of radiation and dissipation.
Sangapatnam SUNEETHA +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Heat transfer to impacting drops and post critical heat flux dispersed flow
, 1978 Heat transfer to drops impacting on a hot surface is examined in context of dispersions of flowing, boiling fluids. The liquid contribution to heat transfer from a hot tube to a two-phase dispersion is formulated in terms of heat transfer contributions ...
Kendall, Gail E., Rohsenow, Warren M.
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Free convection boundary layer flow of a viscoelastic fluid in the presence of heat generation [PDF]
, 2011 The present paper considers the steady free convection boundary layer flow of a viscoelastics fluid with constant temperature in the presence of heat generation.
Shafie, Sharidan +2 more
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