Results 91 to 100 of about 2,241,755 (301)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Composição corporal e exigências nutricionais de proteína e energia para cordeiros Morada Nova Body composition and nutritional requirements of protein and energy for Morada Nova lambs

Revista Brasileira de Zootecnia, 2005
Este trabalho foi realizado objetivando-se determinar a composição corporal de proteína, gordura e energia e as exigências nutricionais de proteína e energia para mantença e ganho de peso de ovinos Morada Nova. Foram utilizados 30 cordeiros com peso vivo
Severino Gonzaga Neto, Américo Garcia da Silva Sobrinho, Kleber Tomás de Resende, Nivea Maria Brancacci Lopes Zeola, Aderbal Marcos de Azevedo Silva, Carlo Aldrovandi Torreão Marques, André Gustavo Leão   +6 more
doaj   +1 more source

The challenge of integrating non-continuous processes-milk powder plant case study [PDF]

, 2009
The integration of non-continuous processes such as a milk powder plant present a challenge for existing process integration techniques. Current techniques are generally based on steady and continuous operation which for some industries is not the case ...
Atkins, Martin John, Neale, James R., Walmsley, Michael R.W.   +2 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Effect of Feeding Levels and Physical Activities on Heat Production in Laying Hens under Different Ambient Temperatures

The Journal of Poultry Science, 2002
Eight Single Comb White Leghorn laying hens were used to investigate the effects of feeding levels (FL), ad libitum and 40% feeding, and physical activities on heat production (HP) under different ambient temperatures (Ta) of 25, 29 and 33°C. HP were
I.M. Saiful, Masanori Fujita, Toshio Ito
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Predicting CO2 production of lactating dairy cows from animal, dietary, and production traits using an international dataset

Journal of Dairy Science
: Automated measurements of the ratio of concentrations of methane and carbon dioxide, [CH4]:[CO2], in breath from individual animals (the so-called “sniffer technique”) and estimated CO2 production can be used to estimate CH4 production, provided that ...
M. H Kjeldsen, M. Johansen, M.R. Weisbjerg, A.L.F. Hellwing, A. Bannink, S. Colombini, L. Crompton, J. Dijkstra, M. Eugène, A. Guinguina, A.N. Hristov, P. Huhtanen, A. Jonker, M. Kreuzer, B. Kuhla, C. Martin, P.J. Moate, P. Niu, N. Peiren, C. Reynolds, S.R.O. Williams, P. Lund   +21 more
doaj   +1 more source

Effect of feed intake on heat production and protein and fat deposition in milk-fed veal calves

Animal, 2009
Energy requirements for veal calves have not been updated recently despite the increased age at slaughter and the predominance of the Prim’Holstein breed in Europe.
E. Labussiere, G. Maxin, S. Dubois, J. van Milgen, G. Bertrand, J. Noblet   +5 more
doaj   +1 more source