Results 81 to 90 of about 2,241,755 (301)

Stochastic energetics of a Brownian motor and refrigerator driven by non-uniform temperature

, 2014
The energetics of a Brownian heat engine and heat pump driven by position dependent temperature, known as the B\"uttiker-Landauer heat engine and heat pump, is investigated by numerical simulations of the inertial Langevin equation. We identify parameter
Feynman R. P., Izumida Y., Kloeden P. E., RONALD BENJAMIN, Van den Broeck C., Van den Broeck C.   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Carbon Dioxide Production in Animal Houses: A literature review [PDF]

, 2008
This article deals with carbon dioxide production from farm animals; more specifically, it addresses the possibilities of using the measured carbon dioxide concentration in animal houses as basis for estimation of ventilation flow (as the ventilation ...
Aarnink, A.J.A., Blanes-Vidal, V., Chwalibog, A., Haeussermann, A., Heetkamp, M.J.W., Joergensen, H., Pedersen, S.   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of inflammation stimulation on energy and nutrient utilization in piglets selected for low and high residual feed intake

Animal, 2015
Selection of animals for improved feed efficiency can affect sustainability of animal production because the most efficient animals may face difficulties coping with challenges.
E. Labussière, S. Dubois, H. Gilbert, J.N. Thibault, N. Le Floc’h, J. Noblet, J. van Milgen   +6 more
doaj   +1 more source

Fabrication of Composite Membranes for Solar-thermal Desalination [PDF]

, 2020
With rising human populations, the demand for freshwater is an ever-growing problem. One emerging technology to combat this problem is membrane distillation (MD).
Mason, Andrew, Mohammadighaleni, Mahdi, Nejati, Siamak   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Integral Fluctuation Relations for Entropy Production at Stopping Times

, 2019
A stopping time $T$ is the first time when a trajectory of a stochastic process satisfies a specific criterion. In this paper, we use martingale theory to derive the integral fluctuation relation $\langle e^{-S_{\rm tot}(T)}\rangle=1$ for the stochastic ...
Jülicher, Frank, Neri, Izaak, Pigolotti, Simone, Roldán, Edgar   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Thermal Transients in District Heating Systems

, 2013
Heat fluxes in a district heating pipeline systems need to be controlled on the scale from minutes to an hour to adjust to evolving demand. There are two principal ways to control the heat flux - keep temperature fixed but adjust velocity of the carrier (
Chapple, David G., Hitchmough, Rod A., Patterson, Geoff B.   +2 more
core   +1 more source