Results 61 to 70 of about 2,241,755 (301)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Journal of Poultry Science, 2002 Six Single Comb White Leghorn laying hens (Shaver, Star cross 288) were used to estimate heat production (HP) for physical activities under different lighting regimes (LR) of 12L : 12D, 14L : 10D and 16L : 8D, respectively, fed ad libitum at 25°C. HP
Islam M. Saiful +2 more
doaj +1 more source
Sex difference in initial thermoregulatory response to dehydrated exercise in the heat
Physiological Reports, 2021 Although it is well established that dehydration has a negative impact on thermoregulation during exercise in the heat, it is unclear whether this effect of dehydration is different between men and women, or across the phases of the menstrual cycle (MC).
Gabrielle E. W. Giersch +8 more
doaj +1 more source
Fluctuation Theorems of Brownian Particles Controlled by a Maxwell's Demon
, 2006 We study the stochastic dynamics of Brownian particles in a heat bath and subject to an active feedback control by an external, Maxwell's demon-like agent.
E. Schrödinger +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2000 The sarcoplasmic reticulum of skeletal muscle retains a membrane bound Ca2+-ATPase which is able to interconvert different forms of energy. A part of the chemical energy released during ATP hydrolysis is converted into heat and in the bibliography it is ...
LEOPOLDO DE MEIS
doaj +1 more source
Modelling and simulation of small-scale embedded generation systems [PDF]
, 2002 Advances in heat and power production are leading to a revolution in how buildings are perceived as an energy system. The rapid development of fuel cells, photovoltaic facades, cogeneration and the evolution of ducted windturbines allows the designer to ...
Beausoleil-Morrison, I., Kelly, N.J.
core
Thermal imaging on simulated faults during frictional sliding [PDF]
, 2006 Heating during frictional sliding is a major component of the energy budget of earthquakes and represents a potential weakening mechanism. It is therefore important to investigate how heat dissipates during sliding on simulated faults. We present results
Gundersen, Olav +2 more
core +5 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source