Results 51 to 60 of about 707,197 (266)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Intracontinental Fault Reactivation in High Heat Production Areas of Central Australia: Insights From Apatite Fission Track Thermochronology

Geochemistry, Geophysics, Geosystems, 2022
Pervasive intracontinental orogenesis during the Paleozoic has been widely recognized in the metamorphic and structural records of the Aileron Province and Amadeus Basin in central Australia, commonly attributed to the Ordovician–Carboniferous Alice ...
A. L. Nixon, S. Glorie, N. Fernie, M. Hand, A. T. DeVries Van Leeuwen, A. S. Collins, D. Hasterok, G. Fraser   +7 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of inflammation stimulation on energy and nutrient utilization in piglets selected for low and high residual feed intake

Animal, 2015
Selection of animals for improved feed efficiency can affect sustainability of animal production because the most efficient animals may face difficulties coping with challenges.
E. Labussière, S. Dubois, H. Gilbert, J.N. Thibault, N. Le Floc’h, J. Noblet, J. van Milgen   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estimating maintenance energy requirements of Borgou cattle to improve feeding precision under tropical conditions

Frontiers in Animal Science
IntroductionImproving the energetic efficiency of cattle under tropical conditions is essential to enhance productivity while limiting feed costs and greenhouse gas emissions. The indigenous Borgou breed plays a central role in West African beef systems,
Alassan Seidou Assani, Alassan Seidou Assani, Yaya Idrissou, Ibrahim Alkoiret Traoré, Mirabelle Jésugnon Houngbedji, Hénoc Naitchede, Sorebou Hilaire Sanni Worogo, Cham Donald Alabi, Appolinaire Kouamé Dossa, Nouroudine Alimi, Habirou Sidi Imorou, Aliyassoum Mama Yacoubou, Aliyassoum Mama Yacoubou, Eloi Attakpa, Youssouf Toukourou   +14 more
doaj   +1 more source

Desempenho, eficiência de utilização dos nutrientes e estrutura do trato digestório de pintos de corte alimentados na fase pré-inicial com rações de diferentes formas físicas Performance, efficiency of nutrient utilization and gastrointestinal structures of broiler chick fed in prestarter phase with ratios with different physical form

Revista Brasileira de Zootecnia, 2008
Este estudo foi realizado com o objetivo de avaliar o efeito da forma física da ração sobre o desempenho, a utilização dos nutrientes das rações e o desenvolvimento do trato disgestório de pintos de corte na primeira semana de vida.
Ednardo Rodrigues Freitas, Nilva Kazue Sakomura, Fabiano Dahlke, Fabiana Ramos Santos, Nei André Arruda Barbosa   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source