Results 61 to 70 of about 8,455,902 (295)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
In-cylinder in-depth combustion investigation for a heavy-duty diesel engine
Propulsion and Power ResearchThis present study is part of the design improvement process of a specified high torque low-speed engine. This work aims at carrying out an in-depth analysis of in-cylinder combustion, mesh sensitivity, and engine performance at supercharge conditions to
Anam Ali, Khalid Saifullah Syed
doaj +1 more source
A Simplified Analysis to Predict the Fire Hazard of Primary Lithium Battery
Applied Sciences, 2018 To better understand the fire risk of primary lithium batteries, the combustion properties of different numbers of primary lithium batteries were investigated experimentally in this work. Based on the t2 fire principle and total heat release results from
Mingyi Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Field test of the performance of an energy tunnel employing capillary heat exchangers
Energy and Built EnvironmentThe integration of capillary heat exchangers (CHEs) with tunnel lining to form an energy tunnel represents a viable and effective approach for the efficient utilization of shallow geothermal energy.
Yongming Ji +5 more
doaj +1 more source
Heat, Co And Smoke Release Rates Of Plywood Under A Depleted Oxygen Atmosphere: An Experimental Study Using An Osu Heat Release Rate Apparatus [PDF]
Fire Safety Science, 1991 Proceedings of the Third International Symposium on Fire Safety Science: 08 July 1991, Edinburgh ...
Tsuchiya, Y., Mathieu, J. F.
openaire +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source