Results 71 to 80 of about 1,030,130 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Energies, 2020 Real-scale fire experiments were conducted to understand the fire spread characteristics of the major combustibles handled in traditional markets, a space with high fire risk.
Hong-Seok Yun +2 more
doaj +1 more source
Further Studies on Fire Retardant Polystyrene by Friedel–Crafts Chemistry [PDF]
, 1999 The combination of a copolymer of 4-vinylbenzyl alcohol and styrene with 2-ethylhexyldiphenylphosphate (DPP) and with metal chlorides has been studied by TGA, radiative gasification, Cone Calorimetry, and oxygen index measurements.
Gilman, Jeffery W +3 more
core +1 more source
Methods of determining heat release rate: State-of-the-art
Fire Safety Journal, 1982 The heat release rate of combustible materials gives some insight into their behaviour in fire. In this paper three thermal methods and a gas analysis method of determining heat release rate are reviewed. Delayed response due to thermal inertia of the apparatus and radiative heat release when it is significantly great, are two major problems with the ...
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Damage of woven composite under translaminar cracking tests using infrared thermography [PDF]
, 2017 The aim of this work is to increase the study of the notch translaminar propagation of the woven structures, using the InfraRed Thermography (IRT).
Bouvet, Christophe +3 more
core +4 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
FireA series of fire experiments were conducted in a 0.5 m × 0.5 m × 0.5 m room, and a single door-like opening was adopted. The height of the openings was 20 cm, and the width of the openings varied from 10 cm to 30 cm, with ventilation factors ranging from
Weiheng Li +7 more
doaj +1 more source
On the calculation of heat release rates of IDI engines.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 1989 The heat release rates of an engine with divided combustion chambers have been calculated up to now from the indicated pressures of both chambers (called the gas-flow method here). The enthalpy transfer is estimated by the gas flow, the error of which increases if the pressure ratio between the chambers becomes close to 1.
Ko TERADA +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source