Results 81 to 90 of about 861,106 (356)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Thermodynamics Characterization of Density models for an Effective Solar Water Heater Sizing [PDF]

, 2012
The problem faced in Sizing of an effective Solar Water Heater (SWH) by engineers to meet certain design requirement is highly enormous. Using the thermodynamic characterization relation and the knowledge of Solar Water Heater (SWH) density’s model ...
Aasa, S. A., Ajayi, O. O., Gbenebor, O. P   +2 more
core  

Thermal Technical Requirements for Wall Materials and Analysis of Thermal Stability of Enclosing Structures under Non-Stationary Heat Flow

, 2023
Siranush Egnatosyan, Maria Badalyan, Naira Egnatosyan   +2 more
openalex   +1 more source

Heat Storage for Cooking: A Discussion on Requirements and Concepts [PDF]

, 2023
Ole Jørgen Nydal
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

164 Effect of Supplemental Dl-met Above Requirement on Performance and Serum Concentration of Amino Acids in Heat Stressed Pigs

, 2021
Adriana Morales, Verónica Sánchez, Bayron Pérez, Lucero R Camacho, J. C. González-Vega, John K Htoo, Miguel Cervantes   +6 more
openalex   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Megawatt Class Nuclear Space Power Systems (MCNSPS) conceptual design and evaluation report. Volume 1: Objectives, summary results and introduction [PDF]

The objective was to determine which reactor, conversion, and radiator technologies would best fulfill future Megawatt Class Nuclear Space Power System Requirements.
Wetch, J. R.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Assessment of thermal heat requirement, radiation energy, water use efficiency, and yield of mango cv Dashehari using fertigation method

Journal of Agrometeorology, 2017
Thermal heat requirement as well as energy components depend on weather parameters. Critical phenological stages was taken into consideration for the thermal heat requirement during 2013-15 under fertigation treatment (25, 50 and 75 per cent of ...
TARUN ADAK, KAILASH KUMAR, VINOD KUMAR SINGH   +2 more
doaj   +1 more source