Results 51 to 60 of about 171,704 (286)

Suppression of Heat Shock Protein-70 by Ceramide in Heat Shock-induced HL-60 Cell Apoptosis [PDF]

Journal of Biological Chemistry, 2000
Ceramide has emerged as a mediator of cell growth, differentiation, and apoptosis in many biological systems. Many kinds of stresses are reported to induce apoptosis with an increase of ceramide generation. Here we showed that the intracellular ceramide levels increased in parallel with heat shock (HS)-induced apoptosis in an intensity- and time ...
T, Kondo, T, Matsuda, M, Tashima, H, Umehara, N, Domae, K, Yokoyama, T, Uchiyama, T, Okazaki   +7 more
openaire   +2 more sources

Toxoplasma gondii Strains: Bioinformatic Analysis of Heat shock protein 60 Gene in Experimentally Infected Mice [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2019
Background and study aim: There is a need for more detailed characterisation of T. gondii strains to determine the level of genetic variability which is useful in effective diagnosis, treatment and control of toxoplasmosis.
Mona Mattar, Rania Hamza, Ghada Fathy, Tahani Farag, Howayda Moawad, Enas Elbahaie, Abdelnasser Madboli, Ashraf Barakat   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reactivity to neural tissue epitopes, aquaporin 4 and heat shock protein 60 is associated with activated immune–inflammatory pathways and the onset of delirium following hip fracture surgery

, 2023
Reactivity to neural tissue epitopes, aquaporin 4 and heat shock protein 60 is associated with activated immune–inflammatory pathways and the onset of delirium following hip fracture ...
S Tantavisut (13330584), Y Thipakorn (13330587), A Vojdani (13353897), S Sirivichayakul (13330596), M Maes (13320648), P Thisayakorn (13330581)   +5 more
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation

, 2009
Adipocytes play important roles in lipid metabolism but also in the control of inflammatory processes. Based on our previous findings of heat shock protein (Hsp) 60-induced activation of preadipocytes we investigated whether the capacity of heat shock ...
Märker, Tina, Burkart, Volker, Volker Burkart, Christiane Habich, Gülden, Elke, Kolb-Bachofen, Victoria, Habich, Christiane, Elke Gülden, Tina Märker, Jennifer Kriebel, Victoria Kolb-Bachofen, Kriebel, Jennifer   +11 more
core   +1 more source

Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018
Background Multiple sclerosis (MS) is an autoimmune demyelinating disorder. The etiology of MS remains unknown exactly. Helicobacter pylori heat shock proteins were suggested as a potential trigger of immune system causing MS.
Steven Emil Gerges, Taha Kamel Alosh, Salma Hamed Khalil, Mona Mokhtar Waheed El Din   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Identification and nucleotide sequence of the heat shock protein 60 (GroEL) gene of Bacteroides forsythus

, 1998
Bacteroides forsythus is a Gram negative anaerobe associated with human periodontal disease. Heat shock proteins are immunodominant antigens in bacteria that can elicit strong and protective immune responses. The gene specifying the GroEL protein (hsp60,
Riggio, Marcello P., Reid, Helen I.
core   +1 more source

Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression

Neoplasia: An International Journal for Oncology Research
Background: Glioblastoma (GBM) poses a significant medical challenge due to its aggressive nature and poor prognosis. Mitochondrial unfolded protein response (UPRmt) and the heat shock factor 1 (HSF1) pathway play crucial roles in GBM pathogenesis.
Xiang Li, Zongqi Wang, Bixi Gao, Kun Dai, Jiang Wu, Kecheng Shen, Guangzhao Li, Xiaowang Niu, Xin Wu, Longyuan Li, Haitao Shen, Haiying Li, Zhengquan Yu, Zhong Wang, Gang Chen   +14 more
doaj   +1 more source