A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
Advanced Science, EarlyView.A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu +7 more
wiley +1 more source
Supplementary Figure 4 from Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2<sup>+</sup> Tumor Cell Recognition by Specific CD8<sup>+</sup> T Cells [PDF]
, 2023 Mayumi Kawabe +6 more
openalex +1 more source
Computational Polypharmacology Analysis of the Heat Shock Protein 90 Interactome
Journal of Chemical Information and Modeling, 2015 The design of a single drug molecule that is able to simultaneously and specifically interact with multiple biological targets is gaining major consideration in drug discovery. However, the rational design of drugs with a desired polypharmacology profile is still a challenging task, especially when these targets are distantly related or unrelated.
Anighoro, Andrew +6 more
openaire +3 more sources
Advanced Science, EarlyView.Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu +11 more
wiley +1 more source
Μελέτη της πρωτεΐνης heat shock protein 90 (HSP90) σε καρκινικά φαινόμενα [PDF]
, 2009 Dimitris Stellas
openalex +1 more source
Supplementary Figure 3 from Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2<sup>+</sup> Tumor Cell Recognition by Specific CD8<sup>+</sup> T Cells [PDF]
, 2023 Mayumi Kawabe +6 more
openalex +1 more source
Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome
Advanced Science, EarlyView.By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang +12 more
wiley +1 more source
Supplementary Figure 1 from The Heat Shock Protein 90 Inhibitor IPI-504 Induces KIT Degradation, Tumor Shrinkage, and Cell Proliferation Arrest in Xenograft Models of Gastrointestinal Stromal Tumors [PDF]
, 2023 Giuseppe Floris +9 more
openalex +1 more source
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
The 90-kDa Heat-shock Protein (Hsp90)-binding Immunophilin FKBP51 Is a Mitochondrial Protein That Translocates to the Nucleus to Protect Cells against Oxidative Stress [PDF]
, 2011 Luciana I. Gallo +3 more
openalex +1 more source