Results 151 to 160 of about 309,378 (343)

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Serum Heat Shock Protein 90 Alpha: A New Marker of Hypertension-Induced Endothelial Injury? [PDF]

, 2015
Katarzyna Skórzyńska-Dziduszko, Anna Olszewska, Monika Prendecka, Teresa Małecka‐Massalska   +3 more
openalex   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Heat shock protein 90 (Hsp90) [PDF]

Science-Business eXchange, 2009
  +6 more sources

Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells [PDF]

, 2014
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung‐Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee   +6 more
openalex   +1 more source

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery

Signal Transduction and Targeted Therapy, 2021
Lili Cai, Lihui Li, Xihui Chen, Lijun Jia   +3 more
doaj   +1 more source

Efficacy of the Heat shock protein-90 inhibitor geldanamycin against Aspergillus terreus

Studies in Fungi
Aspergillus terreus is increasingly recognised as a pathogen in individuals with compromised immune systems. Given its inherent resistance to amphotericin B and development of resistance to azoles, echinocandins, and other antifungal treatments, the ...
Neha, Sonia Kumari Shishodia, Jata Shankar   +2 more
doaj   +1 more source

The refolding activity of the yeast heat shock proteins Ssa1 and Ssa2 defines their role in protein translocation. [PDF]

, 1996
Ssa1/2p, members of one of the yeast cytosolic hsp70 subfamilies, have been implicated in the translocation of secretory proteins into the lumen of the ER.
Bush, GL, Meyer, DI
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