Results 191 to 200 of about 309,378 (343)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

A centralized interactive tool for genomic data on heat shock protein 90 in Fagaceae species. [PDF]

BMC Genomics
Postigo-Luque R, Guijo-Rubio D, Martín MÁ, Castro P, Die JV.   +4 more
europepmc   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Heat shock protein 90 (Hsp90) [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

The evolution of heat shock protein 90 C-terminal inhibitors: From novobiocin to potential clinical candidates. [PDF]

Cell Stress Chaperones
Jiang X, Blagg BSJ.
europepmc   +1 more source

Figure 3 in The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth

, 2017
Hongchao Sun, Xunhui Zhuo, Xianfeng Zhao, Yi Yang, Xueqiu Chen, Chaoqun Yao, Aifang Du   +6 more
openalex   +1 more source

Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor-α Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90 [PDF]

, 2007
Warren Fiskus, Yuan Ren, Alex Mohapatra, Purva Bali, Aditya Mandawat, Rekha Rao, Bryan Herger, Yonghua Yang, Peter Atadja, Jie Wu, Kapil N. Bhalla   +10 more
openalex   +1 more source

Machine Learning Interatomic Potentials for Energy Materials: Architectures, Training Strategies, and Applications

Advanced Energy Materials, EarlyView.
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park, Saeed Pourasad, Jinhong Mun, Arunkumar Chitteth Rajan, Tae Hyeon Park, Anand Rohit, Mohammad Zafari, Tan‐Lien Pham, Eunjae Jung, Bonseung Koo, Miran Ha, Gi Beom Sim, Hyun Gyu Park, Won Woong Choi, Kwanghyeon Jo, Soohaeng Yoo Willow, David ChangMo Yang, Chang Woo Myung, Geunsik Lee, Kwang S. Kim   +19 more
wiley   +1 more source

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation. [PDF]

Int J Mol Med
Wu K, Xu W, You Q, Guo R, Feng J, Zhang C, Wu W.   +6 more
europepmc   +1 more source

Heat shock protein 90 inhibition attenuates inflammation in models of atopic dermatitis: a novel mechanism of action. [PDF]

Front Immunol, 2023
Ben Abdallah H, Bregnhøj A, Ghatnekar G, Iversen L, Johansen C.   +4 more
europepmc   +1 more source