Results 301 to 310 of about 309,378 (343)

Revealing Propolis Potential Activity on Inhibiting Estrogen Receptor and Heat Shock Protein 90 Overexpressed in Breast Cancer by Bioinformatics Approaches. [PDF]

Bioinform Biol Insights
Simanjuntak MV, Jauhar MM, Syaifie PH, Arda AG, Mardliyati E, Shalannanda W, Hermanto BR, Anshori I.   +7 more
europepmc   +1 more source

The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice. [PDF]

PLoS One
Ben Abdallah H, Marino G, Idorn M, S Reinert L, Bregnhøj A, Paludan SR, Johansen C.   +6 more
europepmc   +1 more source

Neonatal α-Ketoglutaric Acid Gavage May Potentially Alleviate Acute Heat Stress by Modulating Hepatic Heat Shock Protein 90 and Improving Blood Antioxidant Status of Broilers. [PDF]

Animals (Basel)
Gupta V, Goel A, Ncho CM, Jeong CM, Choi YH.   +4 more
europepmc   +1 more source

Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa: A Parallel-Design Double-Blind Trial.

JAMA Dermatol
Ben Abdallah H, Bregnhøj A, Emmanuel T, Ghatnekar G, Johansen C, Iversen L.   +5 more
europepmc   +1 more source

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Heat shock protein 90

Current Opinion in Oncology, 2003
Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signaling proteins, as well as multiple mutated, chimeric, or overexpressed signaling proteins, which promote cancer cell growth or survival or both.
Len, Neckers, S Percy, Ivy
openaire   +2 more sources

Targeting Heat Shock Protein 90 for Malaria

Mini-Reviews in Medicinal Chemistry, 2013
Heat shock protein 90 (Hsp90), an ATP-dependent molecular chaperone, is a highly conserved and ubiquitously expressed stress protein in eukaryotes. It is responsible for activation of various proteins involved in signal transduction, cell cycle control, hormone signaling, and transcription.
Anup S, Ramdhave, Dhaval, Patel, I, Ramya, Mukesh, Nandave, Prashant S, Kharkar   +4 more
openaire   +2 more sources

The heat shock protein 90 of Leishmania donovani

Medical Microbiology and Immunology, 2001
The 90-kDa heat shock protein (Hsp90) of Leishmania donovani is a highly abundant cytoplasmic protein and is involved in a variety of cellular processes. Pharmacological deactivation of Hsp90 leads to growth arrest and induces the synthesis of heat shock proteins. Moreover, treatment of promastigote parasites with Hsp90 inhibitors induces the synthesis
M, Wiesgigl, J, Clos
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Heat Shock Protein 90 Inhibitors as Therapeutic Agents

Recent Patents on Anti-Cancer Drug Discovery, 2012
The molecular chaperone heat shock protein 90 (HSP90) is essential for the folding stability, intracellular disposition and proteolytic turnover of many of the key regulators of cell growth, differentiation and survival. These essential functions are used by the cells during the oncogenesis process to allow the tumor transformation and facilitate the ...
Gomez Monterrey I, SALA, MARINA, Musella S, CAMPIGLIA, Pietro   +3 more
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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90

Journal of Medicinal Chemistry, 2012
Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second generation inhibitor of heat shock protein 90 (Hsp90) and is substantially more potent in vitro and in vivo than the first generation inhibitor 14 (BIIB021) that completed phase II clinical trials ...
Jiandong, Shi, Ryan, Van de Water, Kevin, Hong, Ryan B, Lamer, Kenneth W, Weichert, Cristina M, Sandoval, Srinivas R, Kasibhatla, Marcus F, Boehm, Jianhua, Chao, Karen, Lundgren, Noelito, Timple, Rachel, Lough, Gerardo, Ibanez, Christina, Boykin, Francis J, Burrows, Marilyn R, Kehry, Theodore J, Yun, Erin K, Harning, Christine, Ambrose, Jeffrey, Thompson, Sarah A, Bixler, Anthone, Dunah, Pamela, Snodgrass-Belt, Joseph, Arndt, Istvan J, Enyedy, Ping, Li, Victor S, Hong, Andres, McKenzie, Marco A, Biamonte   +28 more
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