Results 41 to 50 of about 237,771 (309)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies

Journal of Hematology & Oncology
Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and cellular functions.
Wei-Fang Zuo, Qiwen Pang, Xinyu Zhu, Qian-Qian Yang, Qian Zhao, Gu He, Bo Han, Wei Huang   +7 more
doaj   +1 more source

Expression of Hsp72 in Lymphocytes in Patients with Febrile Convulsion

Kaohsiung Journal of Medical Sciences, 2005
The pathophysiology of febrile convulsion, the most common childhood neurologic disease, remains unclear. In this study, we investigated what role a heat shock protein plays in this disease.
Lung-Chang Lin
doaj   +1 more source

Proteomic analysis of the heat shock and acclimation responses of Cyanobacteria [PDF]

, 2005
The cyanobacterium Synechocystis sp. PCC 6803 is a model experimental organism for proteomic research because its entire genomic sequence is available and cyanobacteria have high adaptive potential towards a variety of environmental stresses.
Hall, John James
core  

Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis [PDF]

, 2001
Background—Studies have suggested that the prevalence of antibodies against heat-shock proteins (HSPs), Chlamydia pneumoniae (Cpn), and cytomegalovirus (CMV) is associated with coronary artery disease (CAD), but the independent or joint effects of ...
Virók Dezső, Gönczöl Éva, Prohászka Zoltán, Burián, Katalin, Endrész Valéria, Duba Jenő, Füst György, Kis, Zoltán, Virók, Dezső, Endrész, Valéria, Duba, Jenő, Boda, Krisztina, Berencsi Klára, Berencsi, Klára, Kis Zoltán, Romics, László, Romics László, Gönczöl, Éva, Prohászka, Zoltán, Horváth, Laura, Boda Krisztina, Burián Katalin, Horváth Laura, Füst, György   +23 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Two sides of the same coin: heat shock proteins as biomarkers and therapeutic targets for some complex diseases

Frontiers in Molecular Biosciences
Heat shock proteins are molecular chaperones that play crucial roles in the folding and unfolding of complex polypeptides within the cellular system. These molecules are involved in various processes, including vesicular transport, prevention of protein ...
Xolani Henry Makhoba
doaj   +1 more source

Heat Shock Proteins in Fish Health and Diseases: A Pharmacological Perspective

, 2017
Disease outbreaks are considered one of the largest constraints for the sustainable development of the aquaculture sector. Though applications of antibiotics manage to control and prevent infectious microbial diseases, however, its extensive uses have ...
Parisa Norouzitallab, Peter Bossier, Baruah, Kartik,, Sveriges lantbruksuniversitet., Kartik Baruah, Norouzitallab, Parisa,   +5 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source