Results 61 to 70 of about 591,362 (261)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Magnetohydrodynamic water-based hybrid nanofluid flow comprising diamond and copper nanoparticles on a stretching sheet with slips constraints

open access: yesOpen Physics
Hybrid nanofluid problems are used for augmentation of thermal transportation in various industrial applications. Therefore, the present problem is studied for the heat and mass transportation features of hybrid nanofluid caused by extending surface ...
Yasmin Humaira   +5 more
doaj   +1 more source

Insights of Joule heating and chemical reaction effects on Casson-Williamson fluid in a thermally active Darcy-Forchheimer medium

open access: yesAl-Qadisiyah Journal for Engineering Science
This work examines the two-dimensional continuous flow of a Casson-Williamson fluid over a stretched surface under a Darcy-Forchheimer permeable medium. Several elements can affect the flow, including Joule heating, radiation, chemical reactions, thermal
Vardireddy Sujatha   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Gas Emissions in Combustion of Biofuel

open access: yesActa Technologica Agriculturae, 2014
Nowadays, biomass or more precisely biofuel is more and more being exploited as a substitute for fossil fuels for heating as well as for example for heating a drying environment.
Vitázek Ivan   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Modeling and heat transfer analysis of magnetized hybrid micropolar blood-based nanofluid flow in Darcy–Forchheimer porous stenosis narrow arteries

open access: yesOpen Physics
This article provides a concise comparative examination of how heat generation affects the flow of a magnetized micropolar blood-based hybrid nanofluid (HNF) via a stenotic artery. The effects of Joule heating and viscous dissipation are considered.
Shah Zahir   +6 more
doaj   +1 more source

Plane Strain Deformation In A Thermoelastic Microelongated Solid With Internal Heat Source

open access: yesInternational Journal of Applied Mechanics and Engineering, 2015
The purpose of this paper is to study the two dimensional deformation due to an internal heat source in a thermoelastic microelongated solid. A mechanical force is applied along an overlaying elastic layer of thickness h .
P. Ailawalia   +2 more
doaj   +1 more source

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