Results 61 to 70 of about 5,462,643 (288)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Development and Performance Evaluation of a Multi-Heat Source Plantain Roaster
Nigerian Journal of Technological Development, 2020 The increasing demand for roasted plantain has brought about recent interest to upgrade the local method of roasting to be more user-friendly, hygienic and versatile.
M. O. Jimoh +2 more
doaj
Ground as a source of heat for heat pumps
Journal of Mechanical and Energy Engineering, 2018 Heat pumps are an ideal solution for use in newly built passive and energy-plus buildings. One of the many problems present in such construction is the choice of the operational parameters of the lower heat source and the selection of a ground regeneration system which would enable effective regeneration in a short period of time and at a minimal cost.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Vietnam Journal of Mechanics, 2015 Ventilated air flow in an enclosure is often unsteady (turbulent) at even very low Reynolds number (Re). Meantime natural convection in a box is stationary motion at large enough Rayleigh number (Ra).
T. V. Tran, N. T. Thuy
doaj +1 more source
Proceedings of the workshop on ground-source heat pumps
, 1987 SIGLEAvailable from IEA Heat Pump Center, Eggenstein-Leopoldshafen (DE) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische ...
Calm, J.M. (ed.) +1 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Experimental and Numerical Study on a Dry-expansion Shell-and-Tube Evaporator Used in Wastewater Source Heat Pump (WWSHP) [PDF]
, 2012 Aiming at the issue of bio-fouling build-up on heat exchanger\u27s surface in wastewater source heat pump (WWSHP) systems, a novel dry-expansion shell-and-tube wastewater evaporator (DESTE) with defouling function was developed.
Wang, Xinlei +3 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source