Results 41 to 50 of about 588,170 (264)
Does light attract piglets to the creep area?
Animal, 2015 Hypothermia, experienced by piglets, has been related to piglet deaths and high and early use of a heated creep area is considered important to prevent hypothermia.
M.L.V. Larsen, L.J. Pedersen
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
International Journal of Applied Mechanics and Engineering, 2020 The aim of the paper is to investigate an oscillatory fluid flow and heat transfer through a porous medium between parallel plates in the presence of an inclined magnetic field, radiative heat flux and heat source.
T. Mehta, R. Mehta, A. Mehta
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Engineering Structures and Technologies, 2011 Fire safety is one of the main requirements with respect to the regulations on the buildings involved into the category of human hazards. Human safety measures are applied equally to inhabitants, users, customers, spectators, etc., as well as to fire ...
Jerzy Gałaj +2 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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Ground as a source of heat for heat pumps
Journal of Mechanical and Energy Engineering, 2018 Heat pumps are an ideal solution for use in newly built passive and energy-plus buildings. One of the many problems present in such construction is the choice of the operational parameters of the lower heat source and the selection of a ground regeneration system which would enable effective regeneration in a short period of time and at a minimal cost.
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Development and Performance Evaluation of a Multi-Heat Source Plantain Roaster
Nigerian Journal of Technological Development, 2020 The increasing demand for roasted plantain has brought about recent interest to upgrade the local method of roasting to be more user-friendly, hygienic and versatile.
M. O. Jimoh +2 more
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