Results 131 to 140 of about 222,334 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

How Heat-Powered Heat Pumps Could Reduce the Need for Grid-Scale Energy Storage

This paper explores how the deployment of "High-Performance Heat-Powered Heat Pumps" (HP 3 s)-a novel heating technology-could help meet the domestic heating demand in the UK and reduce how much grid-scale energy storage is needed in comparison to a ...
Cardenas, Bruno, Bruno Cardenas, Garvey, Seamus D., Mehdipour, Ramin, Ramin Mehdipour, Baniamerian, Zahra, Seamus D. Garvey, Zahra Baniamerian   +7 more
core   +2 more sources

Evaporative Heat and Mass Transfer from the Free Surface of a Liquid Wicked into a Bed of Spheres

, 2011
Evaporation of ethanol from square packed arrays of 3.95 mm diameter copper spheres in a transparent, enclosed chamber is investigated. The enclosure ensures that relatively saturated vapor conditions exist near the free surface. The desired heat flux is
Garimella, Suresh V., Christopher P. Migliaccio, Garimella, S V, Migliaccio, Christopher P., Suresh V. Garimella   +4 more
core   +2 more sources

A New Approach to the Economic Evaluation of Thermomodernization: Annual Assessment Based on the Example of Production Space

Energies
Energy and economic assessments are of great relevance in the context of decision processes for the most optimal solutions for building renovations. Following the method recommended by UNIDO, economic analyses of thermal modernization options are carried
Orest Voznyak, Edyta Dudkiewicz, Marta Laska, Ievgen Antypov, Nadiia Spodyniuk, Iryna Sukholova, Olena Savchenko   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Heat Roadmap Europe : Identifying strategic heat synergy regions

, 2014
This study presents a methodology to assess annual excess heat volumes from fuel combustion activities in energy and industry sector facilities based on carbon dioxide emission data.
Möller, Bernd, Werner, Sven, Persson, Urban,, Persson, Urban, Werner, Sven,, Möller, Bernd,   +5 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source