Results 71 to 80 of about 222,334 (313)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Optimization of Temperature Schedule Parameters on Heat Supply in Power-and-Heat Supply Systems

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2009
The paper considers problems concerning optimization of a temperature schedule in the district heating systems with steam-turbine thermal power stations having average initial steam parameters. It has been shown in the paper that upkeeping of an optimum network water temperature permits to increase an energy efficiency of heat supply due to additional ...
V. A. Sednin, A. V. Sednin, M. L. Bogdanovich   +2 more
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Influence of Local Zones of Intensive Heat Transfer on Thermal Regime of Heat Supply Objects

, 2015
The results of mathematical simulation of conjugate heat transfer for heat supply object are represented. The turbulent regime of air motion in a closed cavity with the enclosing walls from reinforced concrete and glass is examined. On the outer boundary,
Maksimov, Vyacheslav Ivanovich, Olga V. Stepanova, Nagornova, Tatiana Aleksandrovna, Tatiana A. Nagornova, Stepanova, Olga, Vyacheslav I. Maksimov   +5 more
core   +1 more source

Commercial effectiveness assessment of implementation the energy efficiency raising of the building project due to introduction of automatic heat consumption control

SHS Web of Conferences, 2017
Introduction of the automated metering stations and regulation (AUU) located directly in the heated building besides creation of comfortable conditions indoors leads to decrease in consumption of thermal energy.
Zvonareva Yu.N., Vankov Yu.V., Shlychkov V.V.   +2 more
doaj   +1 more source

Analysis of the Power Supply Restoration Time after Failures in Power Transmission Lines

Energies, 2020
This paper presents the analysis of power supply restoration time after failures occurring in power lines. It found that the power supply restoration time depends on several constituents, such as the time for obtaining information on failures, the time ...
Alexander Vinogradov, Vadim Bolshev, Alina Vinogradova, Michał Jasiński, Tomasz Sikorski, Zbigniew Leonowicz, Radomir Goňo, Elżbieta Jasińska   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Hybrid Heat Pump for Micro Heat Network [PDF]

, 2017
Achieving nearly zero carbon heating continues to be identified by UK government analysis as an important feature of any lowest cost pathway to reducing greenhouse gas emissions.
Stewart, M., Y. Khalid, M. J. Stewart, Counsell, John M., Khalid, Yousaf, J. M. Counsell   +5 more
core   +1 more source