Results 81 to 90 of about 222,334 (313)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Numerical Analysis of Heat Transfer in a Double-Pipe Heat Exchanger for an LPG Fuel Supply System

LPG fuel supply systems are increasingly important for improving energy efficiency and reducing carbon emissions in the shipping industry. The primary objective of this research is to investigate the heat transfer phenomena to enhance the thermal ...
Younghun Kim, Ancheol Choi, Sungwoong Choi, Seongwoo Lee   +3 more
core   +1 more source

A heat pump system for simultaneous comfort floor cooling and domestic hot water

, 2023
The benefit of ultra-low temperature district heating systems (ULTDH) is their low supply temperature, which increases the heat generation efficiency and significantly reduces the heat loss of the DH network. The present study proposed a dual-effect heat
Zhu, Tingting, Elmegaard, Brian, Liang, Jierong, Rohlfs, Wilko, Gudmundsson, Oddgeir, Thorsen, Jan Eric   +5 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evaporation and desalination using a solar concentrator in an agricultural complex [PDF]

E3S Web of Conferences
The purpose of the article is to study boiling and distilling water using solar concentrator, the actual application and profitability of using such a method of liquid evaporation.
Dudkin Maksim, Vasilev Kirill, Kovalyov Anton   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Photovoltaic panel and wind turbine as an electric energy source for water evaporation and desalination [PDF]

E3S Web of Conferences
The purpose of the article is to study the process of heating and desalination of seawater due to electricity from wind turbines and solar panels. This electric current is collected and transmitted through wires to be used to power electrical devices ...
Dudkin Maksim, Egorov Vadim, Ryavkin Gleb   +2 more
doaj   +1 more source

Realiability Of Heat Supply Subsystem [PDF]

Journal of KONBiN, 2015
Abstract The article presents the reliability analysis of subsystem of heat supply in the example of 47 thousand inhabitants’ city. The analysis was made on the basis of operational data made available by the Municipal Heating Company, between the years 2001 ÷ 2012.
openaire   +1 more source