Results 61 to 70 of about 185,741 (267)
CFD Simulations of Natural Convection Heat Transfer in Enclosures with Varying Aspect Ratios
Chemical Engineering Transactions, 2015 Buoyancy driven natural convection in enclosures has wide range of engineering applications in heat transfer processes. The study of fluid flow and heat transfer characteristics in enclosures has significant importance towards thermal management and ...
R. Pendyala, Y.S. Wong, S.U. Ilyas
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Experimental Study for Heat Transfer Characteristics of Vertical Rectangular Narrow Channels
Zhileng xuebao, 2014 Ionized water was used to investigate the heat transfer characteristics of vertical rectangular narrow channels experimentally. The distribution characteristics of wall-temperature and the local heat transfer coefficient were analyzed by using single ...
Liu Xiaode +3 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Cross-Scale Simulation Study of Porous Medium Heat Exchangers Based on Reliable Cell Selection
EnergiesThis study compares the heat transfer and pressure drop of three cell structures, namely Kelvin cells (KCs), ellipsoidal Kelvin cells (EKCs), and body-centered cubic (BCC) structures, at the cell scale in order to identify the superior configuration ...
Yiqiang Liang +4 more
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A Study on Heat-Transfer Characteristics by a Ground-Heating Method [PDF]
Sustainability, 2018 The ground-heating method using the electric heating pipe improves many problems of the conventional soft-ground improvement method and the ground-heating method using fossil fuel. However, in order to use this method practically, it is necessary to experimentally verify the temperature change due to the discharge of water vapor, and also to compare ...
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Study on Flow Boiling Heat Transfer Characteristics of R404A in Small-diameter Tubes
Zhileng xuebao, 2018 The flow boiling heat transfer process of R404A in small-diameter tubes is a very complex physical phenomenon. At present, research on the heat transfer characteristics of R404A is mostly focused on large-diameter tubes, and there has been little ...
Wang Xuedong, Liu Jianhua, Han Saisai
doaj
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source