Results 71 to 80 of about 185,741 (267)

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Research on Fluid Flow and Heat Transfer Characteristics in Channel of Honeycombed Plate Heat Exchanger

open access: yesZhileng xuebao, 2012
The three dimensional physical model and mathematical model of turbulent flow and heat transfer in the channel of honeycombed plate heat exchanger were established, and the corresponding flow field and temperature field was numerically simulated.
Li Longjian, Chen Huan, Wu Zhijuan
doaj  

Start-up and Heat Transfer Characteristics of L-shaped Pulsating Heat Pipe

open access: yesZhileng xuebao, 2022
In this study, an L-shaped pulsating heat pipe was proposed to address the thermal management problem of lithium-ion batteries in electric vehicles. A pulsating heat pipe has a long heating section, a short cooling section, and a short insulation section.
Chi Riguang, Guo Zirui, Gong Xujin
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Study on Heat Transfer and Friction Characteristics of Sinusoidal Wavy Type Cooling Coil

open access: yesZhileng xuebao, 2007
Wavy fin has been applied in evaporators, condensers and terminal equipment heat exchangers of central air conditioning because of its good heat transfer and friction behavior. Sinusoidal wavy fin type cooling coil of central air conditioning was studied
高强, 王秋旺, 王家贵
doaj   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Experimental Investigation of Microchannel Heat Sink with Modified Hexagonal Fins

open access: yesJournal of Applied Fluid Mechanics, 2019
The concept of periodic renewal of boundary layers is a promising technique for the enhancement of heat transfer in microchannels. Extending the above concept, microchannel heatsink with modified hexagonal fins has been proposed for disrupting the flow ...
S. Subramanian   +2 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

A Review on Heat Transfer Enhancement in Shell-and-tube Heat Exchanger of Compression Type Refrigeration and Air Conditioning Unit

open access: yesZhileng xuebao, 2012
Heat exchangers including condenser and evaporator are important equipments in the compression type refrigeration and air conditioning units, and their heat transfer coefficients have a direct effect on the efficiency and cost of the units.
Zhang Zhengguo   +4 more
doaj  

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