Results 71 to 80 of about 184,279 (267)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Study on Flow Boiling Heat Transfer Characteristics of R404A in Small-diameter Tubes

Zhileng xuebao, 2018
The flow boiling heat transfer process of R404A in small-diameter tubes is a very complex physical phenomenon. At present, research on the heat transfer characteristics of R404A is mostly focused on large-diameter tubes, and there has been little ...
Wang Xuedong, Liu Jianhua, Han Saisai
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Experimental Investigation of Microchannel Heat Sink with Modified Hexagonal Fins

Journal of Applied Fluid Mechanics, 2019
The concept of periodic renewal of boundary layers is a promising technique for the enhancement of heat transfer in microchannels. Extending the above concept, microchannel heatsink with modified hexagonal fins has been proposed for disrupting the flow ...
S. Subramanian, K. S. Sridhar, C. K. Umesh   +2 more
doaj  

Start-up and Heat Transfer Characteristics of L-shaped Pulsating Heat Pipe

Zhileng xuebao, 2022
In this study, an L-shaped pulsating heat pipe was proposed to address the thermal management problem of lithium-ion batteries in electric vehicles. A pulsating heat pipe has a long heating section, a short cooling section, and a short insulation section.
Chi Riguang, Guo Zirui, Gong Xujin
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A Review on Heat Transfer Enhancement in Shell-and-tube Heat Exchanger of Compression Type Refrigeration and Air Conditioning Unit

Zhileng xuebao, 2012
Heat exchangers including condenser and evaporator are important equipments in the compression type refrigeration and air conditioning units, and their heat transfer coefficients have a direct effect on the efficiency and cost of the units.
Zhang Zhengguo, Shi Guoquan, Xu Tao, Gao Xuenong, Wang Shuangfeng   +4 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Study on Heat Transfer and Friction Characteristics of Sinusoidal Wavy Type Cooling Coil

Zhileng xuebao, 2007
Wavy fin has been applied in evaporators, condensers and terminal equipment heat exchangers of central air conditioning because of its good heat transfer and friction behavior. Sinusoidal wavy fin type cooling coil of central air conditioning was studied
高强, 王秋旺, 王家贵
doaj   +2 more sources