Results 71 to 80 of about 147,924 (303)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Pendekatan psikologi dakwah menangani histeria remaja muslim di Selangor [PDF]

, 2015
Gejala histeria dalam kalangan remaja di Malaysia merupakan epidemik sosial yang telah lama berlaku dalam masyarakat. Kejadian tersebut mengganggu proses pengajaran dan pembelajaran, psikologi, jasmani dan spiritual remaja.
Saparudin, Intan Farhana
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Flow distribution of supercritical hydrocarbon fuel in parallel regenerative cooling channels under non-uniform heat flux

Propulsion and Energy
Regenerative cooling technology is an important approach for thermal protection in scramjet engines. Non-uniform axial and circumferential heat flow distribution on the combustor leads to improper flow distribution, resulting in reduced cooling ...
Renshuo Zhu, Xinyan Pei, Sihan Zou, Lingyun Hou   +3 more
doaj   +1 more source

Heat transfer model based on diffusion layer theory for dropwise condensation with high non-condensable gas

AIP Advances, 2020
A new heat-transfer model for dropwise condensation with non-condensable gas (NCG) is developed, which can be used in the design and calculations of a dehumidifier in humidification–dehumidification technology.
Weihong Liu, Xiang Ling
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Similarities and differences between flow boiling in microchannels and pool boiling [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Kandlikar, SG   +1 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Heat Transfer Characteristics and Prediction Model of Supercritical Carbon Dioxide (SC-CO2) in a Vertical Tube

Energies, 2017
Due to its distinct capability to improve the efficiency of shale gas production, supercritical carbon dioxide (SC-CO2) fracturing has attracted increased attention in recent years. Heat transfer occurs in the transportation and fracture processes.
Can Cai, Xiaochuan Wang, Shaohua Mao, Yong Kang, Yiyuan Lu, Xiangdong Han, Wenchuan Liu   +6 more
doaj   +1 more source

Optimisation of a high-efficiency solar-driven organic rankine cycle for applications in the built environment [PDF]

, 2018
Energy security, pollution and sustainability are major challenges presently facing the international community, in response to which increasing quantities of renewable energy are to be generated in the urban environment.
Chatzopoulou, Maria Anna, Freeman, James, Ramos Cabal, Alba   +2 more
core   +2 more sources