Results 81 to 90 of about 23,246 (292)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Diameter Effect on the Wall Temperature Behaviors During Supercritical Water Heat Transfer Deterioration in Circular Tubes and Annular Channels

Frontiers in Energy Research, 2019
Diameter effect on heat transfer deterioration (HTD) for supercritical water upward flow in circular tubes and annular channels at low mass flux and high heat flux was studied numerically based on validated turbulence model.
Hui Cheng, Aaron Bai Yanlin, Jun Wang, Jiyun Zhao   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Heat Transfer in Furnace of 1 000 MW Coal-fired Unit Under Different Load Conditions

发电技术, 2019
A 3D coupled mathematical model of 1 000 MW ultra-supercritical tower boiler was established. Based on the design parameters of the boiler, the model calculated the flow and heat transfer process of the boiler in operation. The model was used to simulate
Chu SHI, Ran LI, Zhen YANG, Yuanyuan DUAN   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Numerical investigation on flow and convective heat transfer of aviation kerosene at supercritical conditions

, 2013
avier-Stokes equations were solved using RNG k-epsilon turbulence model with low Reynolds number correction. The thermophysical and transport properties of the China RP-3 kerosene were calculated with a 10-species surrogate and the extended corresponding
Chen LH(陈立红), Zhong, FQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab High Temp Gas Dynam, Beijing 100190, Peoples R China., Zhong FQ(仲峰泉), Zhang XY(张新宇), Dang GX(党国鑫)   +4 more
core   +1 more source

Numerical investigation of heat transfer in parallel channels with water at supercritical pressure

Heliyon, 2017
Thermal phenomena such as heat transfer enhancement, heat transfer deterioration, and flow instability observed at supercritical pressures as a result of fluid property variations have the potential to affect the safety of design and operation of ...
Edward Shitsi, Seth Kofi Debrah, Vincent Yao Agbodemegbe, Emmanuel Ampomah-Amoako   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

On assessment of heat transfer deterioration of a channel with supercritical n-decane for scramjet engines cooling

, 2019
To explore the local heat transfer deterioration (HTD) behavior in cooling channels with the endothermic hydrocarbon fuel for a scramjet engine, the flow and thermal performance of a rectangular channel cooled by supercritical hydrocarbon fuel are ...
Xie G., Li Y., Sun F., Manca O.
core   +1 more source