Results 51 to 60 of about 3,392,706 (249)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
INTENSIFICATION OF HEAT TRANSFER IN A HIGH-TEMPERATURED FLUIDIZED BED
Nauka ta progres transportu, 2017 Purpose. This paper highlights experimental research of heat exchange in coarse particles to ensure the performance of ecological characteristics of Heat supply system. Methodology. The test stand has been developed to solve the defined task. It helps to
А. O. Redko, I. O. Redko
doaj +1 more source
Heat transfer during film condensation of potassium vapor [PDF]
, 1966 The object of this work is to investigate theoretically and experimentally the following two phases of heat transfer during condensation of potassium vapore, a.
Kroger, Detlev Gustav
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Polish Maritime Research, 2017 In the paper, new trends in the development of microchannel heat exchangers are presented. The exchangers developed in this way can be applied in marine industry.
Mikielewicz Dariusz, Wajs Jan
doaj +1 more source
Tables for solution of the heat-conduction equation with a time-dependent heating rate [PDF]
, 1962 Tables are presented for the solution of the transient onedimensional heat flow in a solid body of constant material properties with the heating rate at one boundary dependent on time. These tables allow convenient and rapid estimation of the temperature
Bergles A. E.
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Вестник Дагестанского государственного технического университета: Технические науки, 2019 Objectives. Mathematical modeling of heat transfer in flat channels with turbulators symmetrically located on both its sides, depending on the cross section of the turbulators.Methods.
I. E. Lobanov
doaj +1 more source
The design of mini/micro heat exchangers: A world of opportunities and constraints [PDF]
, 2018 Micro heat exchangers and heat sinks broadened their use in many technological fields during the last two decades. The reduction of the dimensions of the channels allows to obtain ultra-compact heat exchangers characterized by higher surface-to-volume ...
Gian Luca Morini +5 more
core +1 more source