Results 61 to 70 of about 3,392,706 (249)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Impact of Lewis Number on Natural Convection with Double Diffusion in a Square Cavity Filled with Non-Newtonian Fluid with Viscosity Varying with Temperature

Engineering Proceedings
This work focuses on the numerical analysis of double diffusive natural convection inside a square cavity filled with non-Newtonian fluids obeying the power-law model. The viscosity is considered to vary with temperature following an exponential law. The
Mohamed Rahmoun, Bilal El hadoui, Taoufik Makayssi, Mohamed Lamsaadi   +3 more
doaj   +1 more source

Are Intensified Processes Safer and More Reliable than Traditional Processes? An emblematic Case Study

Chemical Engineering Transactions, 2014
One of the best ways of preventing accidents is to avoid hazards by inherently safer design. As many processes, particularly those in the chemicals, nuclear and oil industries, involve the production, handling and use of hazardous substances, process ...
G. Baldissone, G. Cavaglia, M. Demichela
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Heat Transfer Intensification in Recuperative Heat Exchangers of the Stirling Engine

Engineering Proceedings
The non-stationary mode of movement of the working fluid flow in the Stirling engine causes serious difficulties in the design of heat exchangers. In most cases, the operation of conventional commercial heat exchangers is considered under steady-state ...
Abay Dostiyarov, Gulzira Koldassova, Nellya Jamankulova, Aliya Dostiyarova, Iliya Iliev, Ivan Beloev   +5 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

INTENSIFICATION OF HEAT- AND MASS TRANSFER IN EVAPORATION - CONDENSATION DEVICES

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2005
Results of investigation of capillary structure properties used in evaporation – condensation devices are presented.Constructive solutions for intensification of heat transfer in evaporation and condensation heat exchangers are offered. The obtained heat
A. G. Kulakov
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The effect of porous coatings obtained by various methods on heat transfer and crisis phenomena during nitrogen boiling including non-stationary heating and cooling [PDF]

E3S Web of Conferences
The paper presents the main results of experimental investigation of the influence of porous coatings obtained by various methods on heat transfer and crisis phenomena during nitrogen boiling, including unsteady heating and cooling regimes.
Kuznetsov Denis, Pavlenko Aleksndr
doaj   +1 more source