Results 71 to 80 of about 937,664 (309)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Heat Transfer Performance of Flat Pulsating Heat Pipe with Single-sided Wave Plate
Zhileng xuebao, 2014 Heat transfer performance of a flat pulsating heat pipe with single-sided wave plate was experimentally investigated. Influence factors of heat transfer performance were analyzed under the effect of forced air convection cooling conditions, including ...
Xiahou Guowei, Kong Fangming, Xie Mingfu
doaj
Case Studies in Thermal EngineeringTriply periodic minimal surfaces (TPMS) show superior advantages for efficient thermal management of heat exchanger because of high area-to-volume ratio and excellent overall heat transfer performance.
Zijian Zhang, Zhengying Wei, Junfeng Li
doaj +1 more source
Heat transfer characteristics of hydrid microjet-microchannel cooling module [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +2 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Nanocellulose aerogel-based porous coaxial fibers for thermal insulation [PDF]
, 2020 Strong, continuous, and highly porous coaxial fibers with cellulose nanofibril (CNF) aerogel core and cellulose-rich sheath were fabricated by wet-spinning hollow fibers and infusing them with aerogel precursor for high-performance thermal insulators ...
Hsieh, YL, Zhou, J
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Numerical modelling of the temperature distribution in a two-phase closed thermosyphon [PDF]
, 2013 Interest in the use of heat pipe technology for heat recovery and energy saving in a vast range of engineering applications has been on the rise in recent years.
Fadhl, B, Jouhara, H, Wrobel, LC
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Flow and heat transfer characteristics of microchannel with grooves structure on sidewalls
河南理工大学学报. 自然科学版ObjectivesIn order to explore the effects of grooves shape on the liquid flow and heat transfer performances in microchannel heat sink（MCHS）， find an optimal groove geometry that can provide an efficient cooling performance with heat transfer enhancement
ZHU Qifeng +5 more
doaj +1 more source