Results 71 to 80 of about 157,809 (262)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Research on the Heat Transfer Performance of Phase Change Heat Storage Heat Exchangers Based on Heat Transfer Optimization

Energies
Thermal storage technology has received increasing attention under the policy of encouraging the development of renewable energy and new clean energy. Optimizing the heat exchange system of phase change thermal storage heat exchangers to obtain better performance has become increasingly urgent. This study comprehensively investigated the actual process
Xiaodong Dong, Chuanhui Zhu
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Cooling and heating season performance of an open counterflow heat-source tower heat pump system in high-humidity climates: An experimental and numerical study.

PLoS ONE
The cooling and heating season performance of an open counterflow heat-source tower heat pump (HTHP) system in high-humidity climates is investigated through an integrated experimental and numerical study, focusing on its year-round operation under ...
Xinhao Liu, Peng Liu, Dinggao Xiao, Yuan Li, Shuangying Yang   +4 more
doaj   +1 more source

EXPERIMENTAL EXAMINATION OF HEAT TRANSFER PERFORMANCE OF THE HEATED RADIANT WALL SYSTEM

Journal of Thermal Engineering, 2018
In recent years, radiant heating systems have been catching more observation under favor of the many advantages such as; energy saving and thermal comfort. However, owing the fact that limited information on the system dynamics and the heat transfer characteristics of radiant systems, conventional systems are still preferred to radiant systems ...
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Relationship between chevron angle and heat transfer performance of plate heat exchangers

Case Studies in Thermal Engineering
The chevron angle (β) of a plate heat exchanger significantly affects its heat transfer performance. This study aims to quantify the relation between heat transfer performance and chevron angle.
Xiaowei Zhu
doaj   +1 more source

Effect of Actual Gas Turbine Operating Conditions on Mist/Steam Cooling Performance in a Ribbed Passage

Energies, 2019
This study numerically examines the effect of actual gas turbine operating conditions on heat transfer characteristics in a ribbed passage with mist/steam cooling.
Jianying Gong, Tieyu Gao, Junxiong Zeng, Jianqiang Hou, Zhen Li   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Assessing the use of PEC and jf methods for strengthening the evaluation of new heat exchangers

Heliyon
The new type of heat exchanger uses the micro heat pipe as the main heat transfer material. Compared with the traditional heat exchanger of the same kind, the performance of the new type of heat exchanger has significantly improved.
Jingang Yang, Zitong Feng
doaj   +1 more source