Results 201 to 210 of about 1,194,338 (254)
Dimerization of human PARP15 is required for NAD+ binding and automodification
The FEBS Journal, EarlyView.This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen +9 more
wiley +1 more source
Heated tobacco smoke components delay tooth movement in a rat model
"Purpose: This study aimed to evaluate the effect of the components of tobacco smoke from heated tobacco products (HTPs), referred to as Tobacco Smoke Components (TSCs), on tooth movement and the number of osteoclasts in rat models. Materials and Methods:
中本, 美嗣 +2 more
core
Breaking the ice: multiple origins of ice‐binding/antifreeze proteins
The FEBS Journal, EarlyView.Ice‐binding proteins (IBPs) evolved independently in many organisms during Cenozoic cooling and glaciation. In flounders, α‐helical IBPs evolved from an antiviral protein, while similar IBPs arose independently from different progenitors in three other fish lineages.
Laurie A. Graham, Peter L. Davies
wiley +1 more source
The FEBS Journal, EarlyView.Streptococcus pneumoniae imports glutathione (GSH) from its obligate human host to defend against oxidative stress. GSH import is facilitated through the substrate binding protein (SBP) GshT, relying on charge complementarity between the protein and ligand.
Sarah E. du Toit +4 more
wiley +1 more source
Management of chronic urticaria: Current status and future prospect
Journal of the European Academy of Dermatology and Venereology, EarlyView.Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman +15 more
wiley +1 more source
Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies
Journal of the European Academy of Dermatology and Venereology, EarlyView.Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar +8 more
wiley +1 more source
Journal of Esthetic and Restorative Dentistry, EarlyView.ABSTRACT Objective To compare the surface roughness, color stability, and translucency of zirconia produced by additive manufacturing (AM) and subtractive manufacturing (SM) after exposure to cigarette smoking. Materials and Methods A total of 60 disc‐shaped specimens were fabricated from 2 methods: AM (INNI Cera BCM W500/1000) and SM (VITA YZ T).
Bengisu Mahmutluoglu +2 more
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.In wheat, phosphorylation of the S‐like RNase TaRNS4 mediated by the kinase TaRLK5 promotes its degradation of Puccinia striiformis f. sp. tritici RNA in the apoplast, enhancing resistance to stripe rust. TaRNS4 can hijack phosphatase TaPP2C10 to relieve its dephosphorylation of TaMAPK6, thereby activating MAPK‐mediated immune responses. ABSTRACT RNase
Qiao Wang +8 more
wiley +1 more source