Results 81 to 90 of about 529,196 (302)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Effect of tobacco moisture content on releases of main components in heated cigarette aerosol

Shipin yu jixie, 2022
Objective: To investigate the effect of moisture content of heated cigarette on releases of aerosol main components. Methods: Three different types of heated cigarettes were used to study the effects of moisture content of cigarette sticks on the release
ZHANG Hu, DUAN Yuan-xing, ZHAO Yang, LI Shi-wei, YANG Liu   +4 more
doaj   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Vaping, heated tobacco, and periodontal health: a systematic review of their effects on inflammation, microbiota, and non-surgical therapy response [PDF]

Exploration of Medicine
Background: The increasing use of electronic cigarettes and heated tobacco products has raised concerns regarding their potential effects on periodontal health.
Gianna Dipalma, Alessio Danilo Inchingolo, Valeria Colonna, Benito Francesco Pio Pennacchio, Roberto Vito Giorgio, Danilo Ciccarese, Andrea Palermo, Francesco Inchingolo, Gaetano Isola, Massimo Corsalini, Grazia Marinelli, Angelo Michele Inchingolo   +11 more
doaj   +1 more source

Aerosol Formation and Transfer in Open- and Closed-Ended Heated Tobacco Products

Contributions to Tobacco and Nicotine Research, 2022
A lit cigarette forms a positive and negative pressure zone by a puff with respect to the position of its paper burn line. Smoke aerosols generated from the two zones are then pulled through the rod under the puff to form the mainstream smoke.
Li Bin, Sun Yue, Fu Lili, Feng Lulu, Lei Ping, Liu Chuan, Han Jingmei, Shang Shanzhai, Wang Shuang, Wang Le, Pan Yonghua, Zhang Qi, Guo Zhongya, Huang Feng, Zhang Mingjian, Tang Jianguo, Wang Bing, Zhang Ke   +17 more
doaj   +1 more source

[In Press] Creating a market for IQOS : analysis of Philip Morris' strategy to introduce heated tobacco products to the Australian consumer market

, 2020
Background: Philip Morris International has made efforts to expand the sale of its heated tobacco product, IQOS, into new domestic markets globally. In Australia, where heated tobacco products are prohibited, the company recently attempted to overturn ...
Burton, Suzan (R16012), Watts, Christina, Freeman, Becky   +2 more
core   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Heated tobacco products: information sheet. [PDF]

, 2020
Heated tobacco products (HTPs) pose challenges to regulators, who are facing questions about the unique characteristics and diversity of these products and how to regulate them in the face of aggressive tobacco industry tactics and no internationally ...

core  

Traceability of Agri‐Food Products: The Key to Conscious Trade

Agribusiness, EarlyView.
ABSTRACT Globalization and growing concerns about sustainability have led to improvements in product traceability, quality, and sustainability. Traceability contributes to environmental protection and supports sustainable development by fostering transparency in agricultural practices and encouraging the responsible use of resources.
Scarlett Queen Almeida Bispo, Fernanda Aparecida Silva, Michelle Márcia Viana Martins, Marcelo José Braga Nonnenberg, Ruan da Silva Vianna, Carla Cristina Passos Cruz   +5 more
wiley   +1 more source

Green Ambiguity Shapes Sustainable Investing

Business Strategy and the Environment, EarlyView.
ABSTRACT Green Exchange‐Traded Funds (ETFs) have experienced strong growth in recent years, reflecting increasing investor attention toward sustainability. However, these funds rely on a wide range of environmental metrics that are often weakly aligned, raising concerns about the meaning of greenness in sustainable investing.
Rita Laura D'Ecclesia, Giacomo Morelli, Kevyn Stefanelli   +2 more
wiley   +1 more source