Results 131 to 140 of about 992,907 (313)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The heat is on [PDF]

Nature, 2007
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

IMPLEMENTATION OF NEW TECHNOLOGIES AND EQUIPMENT TILL 2010 AT GAG “MINSK WORKS OF HEATING EQUIPMENT”

Литьë и металлургия, 2006
The brief perspective of implantation of new production of heating equipment till the year 2010 at ОАО *'MZOO'' is given.
S. F. Lukashevich
doaj  

Ion and Electron Heating in ICRF Heating Experiments on LHD

, 2001
"This paper reports on the Ion Cyclotron Range of Frequency (ICRF) heating conducted in 1999 in the 3rd experimental campaign on the Large Helical Device (LHD) with an emphasis on the optimization of the heating regime.
Kawahata, K., Yokoyama, M., Noda, N., Ohakachi, S., Kaneko, O., Suzuki, H., Ozaki, T., Mutoh, T., Isobe, M., Inagaki, S., Kubo, S., Tanaka, K., Zhao, Y., Ida, K., Watanabe, K. Y., Sakakibara, S., Sudo, S., Ikeda, K., deVries, P., Sato, K., Yamamoto, S., Ohyabu, N., Hamada, Y.", Nomura, G., Yamada, I., Narihara, K., Idei, H., Nishimura, K., Shimozuma, T., Peterson, B. J., Shimpo, F., Komori, A., Hartmann, D. A., Osakabe, M., Muto, S., Ashikawa, N., Kado, S., Sakamoto, R., Sasao, H., Motojima, O., Inoue, N., Masuzaki, S., Yamada, H., Emoto, M., Akaishi, K., Takeiri, Y., Minami, T., Torii, Y., Morita, S., Ohkubo, K., Tsumori, K., Krasilnikov, A. V., Yamaguchi, S., Shoji, M., Morisaki, T., Fujiwara, M., Itoh, K., Nakanishi, H., Nakamura, Y., Sasao, M., Miyazawa, J., Sato, M., Seki, T., Goto, M., Toi, K., Kumazawa, R., Oka, Y., Kobuchi, T., Watanabe, T., Funaba, H., "Saito, K., Yamazaki, K., Yokota, M., Tokuzawa, T., Watari, T., Yoshimura, Y., Fukuyama, A., Nagayama, Y., Murakami, S., Sagara, A.   +79 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

INTERNATIONAL SCIENTIFIC AND TECHNICAL CONFERENCE OF FOUNDERS AND METALLURGISTS

Литьë и металлургия, 2004
Information about the International Scientific Conference in Minsk on May 19—21 2004 and Celebration of 50-th Anniversary of Cathedra "Machine and Foundry Production"
Ju. P. Bobrov
doaj  

Heating and processing 1-3000MHz

, 1987
Conf. organised in assoc. with Dielectric Heating Group and Int. Union for ElectroheatAvailable from British Library Document Supply Centre- DSC:87/11299(Heating) / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
British National Committee for Electroheat, London (United Kingdom)
core